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Excitation-metabolism coupling: role of membrane depolarization on the mitochondrial function
(2016)
Depolarizing stimuli induce signaling pathways in muscle that have pleiotropic effects. Two new voltage-dependent phenomena, excitation-transcription and excitation-metabolism coupling (EMC), add to the canonical ...
Membrane cholesterol in skeletal muscle: a novel player in excitation-contraction coupling and insulin resistance
(2017)
Membrane cholesterol is critical for signaling processes in a variety of tissues. We will address here current evidence supporting an emerging role of cholesterol on excitation-contraction coupling and glucose transport ...
Cholesterol removal from adult skeletal muscle impairs excitation–contraction coupling and aging reduces caveolin-3 and alters the expression of other triadic proteins
(2015)
Cholesterol and caveolin are integral membrane components that modulate the function/location of many cellular proteins. Skeletal muscle fibers, which have unusually high cholesterol levels in transverse tubules, express ...
Skeletal muscle excitation-metabolism coupling
(2019)
Mitochondria represent the main source of ATP in skeletal muscle and mitochondria activity increases after muscle fiber depolarization. The regulation of mitochondrial function during contraction in skeletal muscle, however, ...