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Post-translational modifications in DNA topoisomerase 2α highlight the role of a eukaryote-specific residue in the ATPase domain
(Nature Publishing Group, 2018-12)
Type 2 DNA topoisomerases (Top2) are critical components of key protein complexes involved in DNA replication, chromosome condensation and segregation, as well as gene transcription. The Top2 were found to be the main ...
RNA metabolism and ubiquitin/ubiquitin-like modifications collide
(Oxford University Press, 2012-11)
Alternative splicing and post-translational modifications are key events for the generation of proteome diversity in eukaryotes. The study of the molecular mechanisms governing these processes, and every other step of gene ...
Modification of Akt by SUMO conjugation regulates alternative splicing and cell cycle
(Landes Bioscience, 2013-08)
Akt/PKB is a key signaling molecule in higher eukaryotes and a crucial protein kinase in human health and disease. Phosphorylation, acetylation, and ubiquitylation have been reported as important regulatory post-translational ...
Unraveling the effects of peroxiredoxin 2 nitration; role of C-terminal tyrosine 193
(Elsevier Science Inc., 2019-09)
Peroxiredoxins (Prx) are enzymes that efficiently reduce hydroperoxides through active participation of cysteine residues (CP, CR). The first step in catalysis, the reduction of peroxide substrate, is fast, 107 - 108 M−1s−1 ...
Regulating the regulators: Serine/arginine-rich proteins under scrutiny
(John Wiley & Sons Inc, 2012-10)
Serine/arginine-rich (SR) proteins are among the most studied splicing regulators. They constitute a family of evolutionarily conserved proteins that, apart from their initially identified and deeply studied role in splicing ...
An integrative analysis of post-translational histone modifications in the marine diatom Phaeodactylum tricornutum
(BioMed Central, 2015)
Background:
Nucleosomes are the building blocks of chromatin where gene regulation takes place. Chromatin landscapes have been profiled for several species, providing insights into the fundamental mechanisms of ...
An integrative analysis of post-translational histone modifications in the marine diatom Phaeodactylum tricornutum
(BioMed Central, 2015-05)
Background: Nucleosomes are the building blocks of chromatin where gene regulation takes place. Chromatin landscapes have been profiled for several species, providing insights into the fundamental mechanisms of chromatin-mediated ...
SUMOylation and deimination of proteins: two epigenetic modifications involved in Giardia encystation
(Elsevier, 2014-04)
SUMOylation, a post-translational modification of proteins, has been recently described as vital in eukaryotic cells. In a previous work, we analyzed the role of SUMO protein and the genes encoding the putative enzymes of ...
Introduction to transcription factor structure and function
(Elsevier, 2015)
Transcription of eukaryotic genes is regulated by DNA binding proteins known as transcription factors. These factors interact specifically with sequences located in the promoter regions of the genes they regulate. Transcription ...
Identification of new palmitoylated proteins in Toxoplasma gondii
(Elsevier Science, 2016-04)
Protein palmitoylation has been shown to be an important post-translational modification in eukaryotic cells. This modification alters the localization and/or the function of the targeted protein. In recent years, protein ...