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A roadmap to engineering antiviral natural products synthesis in microbes
Natural products continue to be the inspirations for us to
discover and acquire new drugs. The seemingly unstoppable
viruses have kept records high to threaten human health and
well-being. The diversity and complexity ...
Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities
(Elsevier, 2015-06)
Herpes simplex viruses (HSVs) display affinity for cell-surface heparan sulfate proteoglycans with biological relevance in virus entry. This study demonstrates the potential of chemically engineered sulfated xylomannans ...
Exploring lectin-glycan interactions to combat COVID-19: Lessons acquired from other enveloped viruses
(Oxford University Press, 2023)
3D culture models to study SARS-COV-2 infectivity and antiviral candidates: from spheroids to bioprinting
The pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV-2) is receiving worldwide attention, due to the severity of the disease (COVID-19)
that resulted in more than a million global deaths so far. ...
Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral
Objectives: T-705, also known as favipiravir, is a small-molecule inhibitor that is currently in clinical development for the treatment of influenza virus infections. This molecule also inhibits the replication of a broad ...
Single domain antibodies targeting neuraminidase protect against an H5N1 influenza virus challenge
(American Society for Microbiology, 2014-05)
Influenza virus neuraminidase (NA) is an interesting target of small-molecule antiviral drugs. We isolated a set of H5N1 NAspecific single-domain antibodies (N1-VHHm) and evaluated their in vitro and in vivo antiviral ...
Utilização de nanopartículas de poli (ácido láctico-co-glicólico) e de prata na neutralização de SARS-CoV-2: revisão
(Universidade Federal do Rio Grande do NorteBrasilUFRNEngenharia de Materiais, 2020-11-30)
Microorganisms, with their diverse and ample characteristics, are rapidly spread in the environment. Among them, SARS-CoV-2 has gained prominence as it has become a threat to human health and the ecosystems worldwide. ...