Artículos de revistas
Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities
Fecha
2015-06Registro en:
Ray, Sayani; Pujol, Carlos Alberto; Damonte, Elsa Beatriz; Ray, Bimalendu; Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities; Elsevier; Carbohydrate Polymers; 131; 6-2015; 315-321
0144-8617
1879-1344
CONICET Digital
CONICET
Autor
Ray, Sayani
Pujol, Carlos Alberto
Damonte, Elsa Beatriz
Ray, Bimalendu
Resumen
Herpes simplex viruses (HSVs) display affinity for cell-surface heparan sulfate proteoglycans with biological relevance in virus entry. This study demonstrates the potential of chemically engineered sulfated xylomannans from Scinaia hatei as antiHSV drug candidate. Particularly, a dimethylformamide -SO3/pyridine based procedure has been employed for the generation of anionic polysaccharides. This one-step procedure has the power of providing a spectrum of xylomannans with varying molecular masses (<12-74 kDa), sulfate content (1-50%) and glycosyl composition. Especially, the sulfated xylomannans S1F1 and S2F1 possessed altered activity against HSV-1 and HSV-2 compared to the parental compound (F1) and that too in the absence of drug-induced cytotoxicity. Regarding methodological facet, the directive decoration of hydroxyl functionality with sulfate group plus changes in the molecular mass and sugar composition during isolation by the used reagent opens a door for the production of new molecular entity with altered biological activity from other natural sources.