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Short-term induction of thrombocytopenia delays periodontal healing in rats with periodontal disease: participation of endostatin and vascular endothelial growth factor
(Wiley-Blackwell Publishing, Inc, 2010-04-01)
Background and Objective:Platelets contain factors, including VEGF and endostatin, that can modulate the healing process. We evaluated the effects of severe thrombocytopenia on periodontal healing in rats and determined ...
Fibronectin expression is decreased in metastatic renal cell carcinoma following endostatin gene therapy
(Elsevier B.V., 2012-09-01)
Tumor cells induce the disruption of homeostasis between cellular and extracellular compartments to favor tumor progression. the expression of fibronectin (FN), a matrix glycoprotein, is increased in several carcinoma cell ...
Anti-tumor effect of endostatin mediated by retroviral gene transfer in mice bearing renal cell carcinoma
(Federation Amer Soc Exp Biol, 2007-10-01)
We investigated whether transfer of the gene encoding the angiogenesis inhibitor endostatin into the NIH/3T3 fibroblast cell line could inhibit renal tumor growth in vivo. NIH/3T3 cells were transduced with retroviral ...
Endostatin gene therapy enhances the efficacy of IL-2 in suppressing metastatic renal cell carcinoma in mice
(Springer, 2010-09-01)
We investigated whether the administration of IL-2 combined with endostatin gene therapy was able to produce additive or even synergistic immunomodulatory activity in a mouse model of metastatic renal carcinoma. Renca cells ...
Endostatin gene therapy stimulates upregulation of ICAM-1 and VCAM-1 in a metastatic renal cell carcinoma model
(Nature Publishing Group, 2012-08-01)
One of the greatest challenges in urological oncology is renal cell carcinoma (RCC), which is the third leading cause of death in genitourinary cancers. RCCs are highly vascularized and respond positively to antiangiogenic ...
Effect of combined hormonal and insulin therapy on the steroid hormone receptors and growth factors signalling in diabetic mice prostate
(Wiley-Blackwell, 2010-12-01)
P>Diabetes causes harmful effects on prostatic morphology and function. However, there still are doubts about the occurrence of various diseases in the prostate, as well as abnormal angiogenesis in relation to diabetes. ...
Involvement of the NF-kappa B/p50/Bcl-3 complex in response to antiangiogenic therapy in a mouse model of metastatic renal cell carcinoma
(Elsevier B.V., 2014-09-01)
Renal cell carcinoma (RCC) represents approximately 2-3% of human malignancies. Nuclear transcription factor kappa B (NF-kappa B) is composed of a family of transcription factors that have been associated with the development ...
Anti-Angiogenic Effects of the Superantigen Staphylococcal Enterotoxin B and Bacillus Calmette-Guerin Immunotherapy for Nonmuscle Invasive Bladder Cancer
(Elsevier B.V., 2012-02-01)
Purpose: We compared and characterized the effects of intravesical bacillus Calmette-Guerin and/or staphylococcal enterotoxin B for nonmuscle invasive bladder cancer.Materials and Methods: A total of 75 female Fisher 344 ...
Corneal angiogenesis modulation by cysteine cathepsins: in vitro and in vivo studies
(Elsevier B.V., 2015-05-01)
Corneal avascularization is essential for normal vision. Several antiangiogenic factors were identified in cornea such as endostatin and angiostatin. Cathepsin V, which is highly expressed in the cornea, can hydrolyze human ...
Influence of Parstatin on Experimental Periodontal Disease and Repair in Rats
(Amer Acad Periodontology, 2015)