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Immunization with Tc52 or its amino terminal domain adjuvanted with c-di-AMP induces Th17+Th1 specific immune responses and confers protection against Trypanosoma cruzi
(Public Library of Science, 2017-02)
The development of new adjuvants enables fine modulation of the elicited immune responses. Ideally, the use of one or more adjuvants should result in the induction of a protective immune response against the specific ...
A prime-boost immunization with Tc52 N-terminal domain DNA and the recombinant protein expressed in Pichia pastoris protects against Trypanosoma cruzi infection
(Elsevier, 2016-06)
We have previously reported that the N-terminal domain of the antigen Tc52 (NTc52) is the section of the protein that confers the strongest protection against Trypanosoma cruzi infection. To improve vaccine efficacy, we ...
Proof that the high molecular weight immunophilin FKBP52 mediates the in vivo neuroregenerative effect of the macrolide FK506
(Pergamon-Elsevier Science Ltd, 2020-12)
The immunosuppressant drug FK506 (or tacrolimus) is a macrolide that binds selectively to immunophilins belonging to the FK506-binding protein (FKBP) subfamily, which are abundantly expressed proteins in neurons of the ...
Filología. Año 01, número 01
(Universidad de Buenos Aires. Facultad de Filosofía y Letras., 1949-05)
Sumario
(Universidad Nacional del Litoral, 1941-12)
Immunophilins FKBP51 and FKBP52
(MDPI, 2019)
Immunophilins are a family of proteins whose signature domain is the peptidylprolyl-isomerase domain. High molecular weight immunophilins are characterized by the additional presence of tetratricopeptide-repeats (TPR) ...
Galectin-1 Markedly Reduces the Incidence of Resorptions in Mice Missing Immunophilin FKBP52
(Oxford University Press, 2012-05)
Progesterone (P4) signaling is critical for pregnancy.We previously showed that immunopilin FK506 binding protein (FKBP)52 serves as a cochaperone to optimize progesterone receptor (PR) function in the uterus, and its ...
Biological actions of the hsp90-binding immunophilins FKBP51 and FKBP52
(Multidisciplinary Digital Publishing Institute, 2019-08)
Immunophilins are a family of proteins whose signature domain is the peptidylprolylisomerase domain. High molecular weight immunophilins are characterized by the additional presence of tetratricopeptide-repeats (TPR) through ...
Yeast Srs2 helicase promotes redistribution of single-stranded DNA-Bound RPA and Rad52 in homologous recombination regulation
(Elsevier B.V., 2017-10)
Srs2 is a super-family 1 helicase that promotes genome stability by dismantling toxic DNA recombination intermediates. However, the mechanisms by which Srs2 remodels or resolves recombination intermediates remain poorly ...