Buscar
Mostrando ítems 1-10 de 12
Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis
(Academic Press Ltd - Elsevier Science Ltd, 2019-08)
Background: Sepsis-induced cardiomyopathy contributes to the high mortality of septic shock in critically ill patients. Since the underlying mechanisms are incompletely understood, we hypothesized that sepsis-induced ...
Honokiol attenuates oxidative stress-dependent heart dysfunction in chronic Chagas disease by targeting AMPK / NFE2L2 / SIRT3 signaling pathway
(Elsevier Science Inc., 2020-08)
Chronic cardiomyopathyis the most serious and frequent manifestation of Chagas disease caused by Trypanosoma cruzi. Free radicals are acrucial factor in Chagas pathogenesis. Parasite infection of cardiomyocytesexacerbates ...
Endogenous osteopontin induces myocardial CCL5 and MMP-2 activation that contributes to inflammation and cardiac remodeling in a mouse model of chronic Chagas heart disease
(Elsevier Science, 2018-01)
Cardiac dysfunction with progressive inflammation and fibrosis is a hallmark of Chagas disease caused by persistent Trypanosoma cruzi infection. Osteopontin (OPN) is a pro-inflammatory cytokine that orchestrates mechanisms ...
Anti-inflammatory Role of Galectin-8 During Trypanosoma cruzi Chronic Infection
(Frontiers Media S.A., 2020-07)
Galectins are animal lectins with high affinity for β-galactosides that drive the immune response through several mechanisms. In particular, the role of galectin-8 (Gal-8) in inflammation remains controversial. To analyze ...
Defects of mtDNA replication impaired mitochondrial biogenesis during Trypanosoma cruzi infection in human cardiomyocytes and Chagasic patients: The role of Nrf1/2 and antioxidant response
(American Heart Association, 2012-11-29)
Mitochondrial dysfunction is a key determinant in chagasic cardiomyopathy development in mice; however, its relevance in human Chagas disease is not known. We determined if defects in mitochondrial biogenesis and dysregulation ...
Development of orphan coenzyme q10 liquid formulations for pediatric patiens
(Elsevier Science, 2013-08)
Coenzyme Q10 (CoQ10) deficiency is involved in cardiomyopathies and degenerative muscle and neuronal diseases. Most patients with these deficiencies have shown clinical improvement with oral CoQ10 supplementation especially ...
Distrofia muscular de Emery-Dreifuss: la importancia de un estudio ordenado a partir de la clínica y una correcta caracterización etiológico-molecularEmery-Dreifuss muscular dystrophy: The importance of an orderly study based on clinical and correct etiological and molecular characterization
(Ediciones Doyma S A, 2015-07)
Introducción: La distrofia muscular de Emery-Dreifuss (DMED), caracterizada por la tríada clínica de contracturas articulares, debilidad muscular y afectación cardíaca, es genéticamente heterogénea. Causada por mutaciones ...