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Mostrando ítems 1-10 de 2094
Anthelmintic therapy in ruminant species: Understanding of the host-drug-parasite interaction
(Bentham Science Publishers, 2010-05)
Inadequate use of anthelmitic drugs in livestock animals has led to therapeutic failures and to the dramatic widespread development of parasite resistance. Additional scientific knowledge on how to improve the use of ...
Lipid, polymeric, inorganic-based drug delivery applications for platinum-based anticancer drugs
(Elsevier Science, 2021-08)
The three main FDA-approved platinum drugs in chemotherapy such as carboplatin, cisplatin, and oxaliplatin are extensively applied in cancer treatments. Although the clinical applications of platinum-based drugs are extremely ...
Therapeutic drug monitoring in developing nations: Assessing the current state of affairs in South America
(Taylor & Francis, 2021-01)
Therapeutic drug monitoring (TDM) aims to offer assistance to clinicians to improve drug dosing and clinical outcomes, while minimizing the probability of serious adverse effects in routine clinical practice. Disease ...
Evaluation of a lens-free imager to facilitate tuberculosis diagnostics in MODS
(Elsevier, 2015)
Tuberculosis (TB) control efforts are hampered by a mismatch in diagnostic technology. Lack of adequate early diagnostics and Multi-drug resistant (MDR) detection is a critical problem in control efforts. Alternate and ...
Development and Validation of a Computational Model Ensemble for the Early Detection of BCRP/ABCG2 Substrates during the Drug Design Stage
(American Chemical Society, 2017-08)
Breast Cancer Resistance Protein (BCRP) is an ATP-dependent efflux transporter linked to the multidrug resistance phenomenon in many diseases such as epilepsy and cancer and a potential source of drug interactions. For ...
Killing of Cryptosporidium sporozoites by Lactoferrin
(American Society of Tropical Medicine and Hygiene, 2017)
Intestinal infection caused by Cryptosporidium is a major contributor to diarrhea morbidity and mortality in young children around the world. Current treatments for children suffering from cryptosporidiosis are suboptimal. ...
The Thiol-polyamine Metabolism of Trypanosoma cruzi: Molecular Targets and Drug Repurposing Strategies
(Bentham Science Publishers, 2018-09)
Chagas´ disease continues to be a challenging and neglected public health problem in many American countries. The etiologic agent, Trypanosoma cruzi, develops intracellularly in the mammalian host, which hinders treatment ...
New drugs are not enough-drug repositioning in oncology: An update
(Spandidos Publications, 2020-01)
Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that are already known for use treating other diseases. The advantages of this are that several important drug characteristics are ...
Imported strongyloidiasis: Epidemiology, presentations, and treatment
(Springer, 2012)
Strongyloidiasis is extremely more frequent in immigrants than in travellers. Clinical presentations do not differ significantly between the two groups, and the most frequent picture is a chronic infection characterized ...