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The spectrum of tuberculosis described as differential DNA methylation patterns in alveolar macrophages and alveolar T cells
(BioMed Central, 2022)
Background: Host innate immune cells have been identified as key players in the early eradication of Mycobacterium tuberculosis and in the maintenance of an anti-mycobacterial immune memory, which we and others have shown ...
MethylMix 2.0: An R package for identifying DNA methylation genes
(Oxford University Press, 2018-09)
Summary: DNA methylation is an important mechanism regulating gene transcription, and its role in carcinogenesis has been extensively studied. Hyper and hypomethylation of genes is a major mechanism of gene expression ...
Developmental changes and sex differences in DNA methylation and demethylation in hypothalamic regions of the mouse brain
(Landes Bioscience, 2019-08)
DNA methylation is dynamically modulated during postnatal brain development, and plays a key role in neuronal lineage commitment. This epigenetic mark has also recently been implicated in the development of neural sex ...
Early detection of gastric cancer using global, genome-wide and IRF4, ELMO1, CLIP4 and MSC DNA methylation in endoscopic biopsies
(Impact Journals, 2017)
Clinically useful molecular tools to triage gastric cancer patients are not currently available. We aimed to develop a molecular tool to predict gastric cancer risk in endoscopy-driven biopsies obtained from high-risk ...
Blood lead levels in Peruvian adults are associated with proximity to mining and DNA methylation
(Elsevier, 2021)
Background: Inorganic lead (Pb) is common in the environment, and is toxic to neurological, renal, and cardiovascular systems. Pb exposure influences the epigenome with documented effects on DNA methylation (DNAm). We ...
Genome-Wide Epigenetic Signatures of Adaptive Developmental Plasticity in the Andes
(Oxford University Press, 2020)
High-altitude adaptation is a classic example of natural selection operating on the human genome. Physiological and genetic adaptations have been documented in populations with a history of living at high altitude. However, ...
Cell-free DNA methylation as liquid biopsy for the assessment of fibrosis in patients with nonalcoholic steatohepatitis: a gap between innovation and implementation
(AME Publishing Company, 2017-04)
The presence of cfDNA in the circulating compartment was demonstrated three decades ago , leading to the emergence of liquid biopsy.However, the implementation of cfDNA methylation as a non-invasive molecular tool for the ...
Genome-wide analysis of DNA methylation in human amnion
(HINDAWI publishing Corporation, 2013-02)
The amnion is a specialized tissue in contact with the amniotic fluid, which is in a constantly changing state. To investigate the importance of epigenetic events in this tissue in the physiology and pathophysiology of ...
Differential methylation patterns in apomictic vs. Sexual genotypes of the diplosporous grass Eragrostis curvula
(Multidisciplinary Digital Publishing Institute, 2021-05-10)
DNA methylation is an epigenetic mechanism by which a methyl group is added to a cytosine or an adenine. When located in a gene/regulatory sequence it may repress or de-repress genes, depending on the context and species. ...
Methylation-sensitive Amplified Polymorphism as a Tool to Analyze Wild Potato Hybrids
(Bio-protocol LLC, 2020-07)
Methylation-Sensitive Amplification Polymorphism (MSAP) is a versatile marker foranalyzing DNA methylation patterns in non-model species. The implementation of this technique does not require a reference genome and makes ...