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DNA repair BER pathway inhibition increases cell death caused by oxidative DNA damage in Trypanosoma cruzi
(2011)
Trypanosoma cruzi, a parasitic protozoan, is the etiological agent of Chagas disease, an endemic and neglected pathology in Latin America. It presents a life cycle that involves a hematophagous insect and man as well as ...
Melatonin prevents damage elicited by the organophosphorous pesticide diazinon on mouse sperm DNA
(2009)
Toxic effects of pesticides are commonly associated with DNA damage. To evaluate the effect of the organophosphate diazinon on sperm DNA and to test whether melatonin could prevent this damage, male mice were intraperitoneally ...
G2 checkpoint-dependent DNA repair and its response to catalase in Down syndrome and control lymphocyte cultures
(2007)
The amount of DNA lesions repaired in G2 and also G2 timing are controlled by the DNA damage-dependent checkpoint. Down syndrome (DS) lymphocytes showed twice as much constitutive DNA damage in G2 than control ones, when ...
Increased sperm DNA damage in patients with varicocele: relationship with seminal oxidative stress
(OXFORD UNIV PRESS, 2006-04)
BACKGROUND: The pathophysiology of the testicular damage in varicocele has not been completely understood. Oxidative stress and related sperm DNA damage have been identified as significant causes of male infertility. The ...
In vitro study of the protective effect of manganese against vanadium mediated nuclear and mitochondrial DNA damage
(Elsevier, 2020)
We aimed to study the effect of vanadium(V) exposure on cell viability, nuclear DNA (nDNA) and mitochondrial DNA (mtDNA) and to elucidate if these effects can be reverted by co-exposure to V and manganese (Mn). HepG2 cells ...
The overexpression of TcAP1 endonuclease confers resistance to infective Trypanosoma cruzi trypomastigotes against oxidative DNA damage
(Wiley, 2018)
Trypanosoma cruzi, the causative agent of Chagas' disease survives to DNA damage generated by ROS/RNS inside to their different hosts. In recent eukaryotes, oxidative DNA damage is repaired mainly by the Base Excision ...
The DNA-Binding Protein HU has a Regulatory Role in the Acid Stress Response Mechanism in Helicobacter pylori
(Wiley-Blackwell, 2015)
Background: Bacterial genomes are compacted by association with histonelike
proteins to form a complex known as bacterial chromatin. The histonelike
protein HU is capable of binding and bending the DNA molecule, a
function ...
DNA damage, RAD9 and fertility/infertility of Echinococcus granulosus hydatid cysts
(WILEY-LISS, DIV JOHN WILEY & SONS INC, 2008-08)
Hydatidosis, caused by the larval stage of the platyhelminth parasite Echinococcus granulosus, affects human and animal health. Hydatid fertile cysts are formed in intermediate hosts (human and herbivores) producing ...
Bleomycin-induced γH2AX foci map preferentially to replicating domains in CHO9 interphase nuclei
(Kluwer Academic Publishers, 2014)
© 2014, Springer Science+Business Media Dordrecht.Exposure to DNA damaging agents triggers phosphorylation of histone variant H2AX (generating γH2AX) in large chromatin regions flanking DNA lesions, allowing their ...
Chronic hypobaric hypoxia diminishes the expression of base excision repair OGG1 enzymes in spermatozoa
(Wiley, 2018)
Hypobaric hypoxia induces DNA damage in rat testicular cells, the production of defective spermatozoids and decreased sperm count, associated with an increase in oxidative stress. 8-Oxoguanine glycosylase (OGG1) enzymes ...