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Synthesis of C-C bonded dimeric steroids by olefin metathesis
(Pergamon-Elsevier Science Ltd, 2009-05)
Five new C-C bonded steroidal homodimers derived from deoxycholic acid, pregnenolone, and progesterone were synthesized by an olefin metathesis reaction assisted by microwave heating. Microwave improved the yield and ...
More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?
(Taylor, 2017-01-08)
It is widely accepted that the glucocorticoid receptor (GR), a ligand-regulated transcription factor that triggers anti-inflammatory responses, binds specific response elements as a homodimer. Here, we will discuss the ...
Steroid receptor coupling becomes nuclear
(Elsevier, 2012-06-22)
In this issue of Chemistry & Biology, Grossman et al. report a study on aldosterone-dependent nuclear translocation of the mineralocorticoid receptor (MR). They analyze the dependency of MR retrotransport, DNA-binding, and ...
Differential regulation of the glucocorticoid receptor nucleocytoplasmic shuttling by TPR-domain proteins
(Elsevier Science, 2021-05)
A dimer of the heat-shock protein of 90-kDa (Hsp90) represents the critical core of the chaperone complex associated to the glucocorticoid receptor (GR) oligomer. The C-terminal end of the Hsp90 dimer shapes a functional ...
Structural Modeling of GR Interactions with the SWI/SNF Chromatin Remodeling Complex and C/EBP
(Cell Press, 2015-09)
The glucocorticoid receptor (GR) is a steroid-hormone-activated transcription factor that modulates gene expression. Transcriptional regulation by the GR requires dynamic receptor binding to specific target sites located ...
New lead compounds in the search for pure antiglucocorticoids and the dissociation of antiglucocorticoid effects
(Pergamon-Elsevier Science Ltd, 2009-02)
Antiglucocorticoids that act as antagonists at the glucocorticoid receptor (GR) level may be used to block or modulate the undesirable effects of glucocorticoid excess (from endogenous or exogenous origin). RU486 developed ...
La Producción de Metabolitos Secundarios en la Familia Brassicaceae
(Universidad Militar Nueva Granada, 2014)
Un abordaje conceptual y metodológico de la correlación de la estructura química y actividad biológica de tres compuestos anticancerígenos y algunos derivados
(Facultad de Ciencias Exactas y NaturalesManizalesMaestría en Química, 2022)