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Role of the hypothalamic pituitary adrenal axis in the control of the response to stress and infection
(Associação Brasileira de Divulgação Científica, 2000-10)
The release of adrenocorticotropin (ACTH) from the corticotrophs is controlled principally by vasopressin and corticotropin-releasing hormone (CRH). Oxytocin may augment the release of ACTH under certain conditions, whereas ...
Deletion of CRH From GABAergic Forebrain Neurons Promotes Stress Resilience and Dampens Stress-Induced Changes in Neuronal Activity
(Frontiers Media Sa, 2019-09-20)
Dysregulation of the corticotropin-releasing hormone (CRH) system has been implicated in stress-related psychopathologies such as depression and anxiety. Although most studies have linked CRH/CRH receptor 1 signaling to ...
The corticotropin-releasing hormone network and the hypothalamic-pituitary- adrenal axis: Molecular and cellular mechanisms involved
(Karger, 2011-07)
Corticotropin-releasing hormone (CRH) plays a key role in adjusting the basal and stress-activated hypothalamic-pituitary-adrenal axis (HPA). CRH is also widely distributed in extrahypothalamic circuits, where it acts as ...
Endocrinology and the brain: Corticotropin-Releasing Hormone signaling
(BioScientifica, 2017-07-14)
Corticotropin-releasing hormone (CRH) is a key player of basal and stress activated responses in the hypothalamic-pituitary-adrenal axis (HPA) and in extrahypothalamic circuits, where it functions as a neuromodulator to ...
Development of an electrochemical impedimetric immunosensor for Corticotropin Releasing Hormone (CRH) using half-antibody fragments as elements of biorecognition
(2019)
An electrochemical impedimetric immunosensor was developed for the detection of the neuropeptide Corticotropin Releasing Hormone (CRH) based on the immobilization of half-antibody fragments on gold nanoparticles (AuNp). ...
Paraventricular-coerulear interactions: role in hypertension induced by prenatal undernutrition in the rat
(BLACKWELL, 2006-08)
Rats submitted to fetal growth retardation by in utero malnutrition develop hypertension when adult, showing increased hypothalamic mRNA expression for corticotropin-releasing hormone (CRH) and increased central noradrenergic ...
Association between genetic variant rs2267716 of CRHR2 gene with colorectal cancerBMJ Journals
(BMJ Journals. Texas Tech University Health Sciences Center, 2022)
Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety
(Nature Publishing Group, 2018-06-01)
The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe ...