Artículos de revistas
Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety
Fecha
2018-06-01Registro en:
Nature Neuroscience. New York: Nature Publishing Group, v. 21, n. 6, p. 803-+, 2018.
1097-6256
10.1038/s41593-018-0151-z
WOS:000433232600008
Autor
Max Planck Inst Psychiat
Harvard Med Sch
McLean Hosp
Universidade Estadual Paulista (Unesp)
Heidelberg Univ
Helmholtz Zentrum Munchen
Tech Univ Munich
German Ctr Neurodegenerat Dis DZNE
Max Planck Gesell
Institución
Resumen
The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.