Artículos de revistas
Endocrinology and the brain: Corticotropin-Releasing Hormone signaling
Fecha
2017-07-14Registro en:
Inda, María Carolina; Armando, Natalia Giannina; Dos Santos Claro, Paula Ayelen; Silberstein Cuña, Susana Iris; Endocrinology and the brain: Corticotropin-Releasing Hormone signaling; BioScientifica; Endocrine Connections; 6; 6; 14-7-2017; 99-120
2049-3614
CONICET Digital
CONICET
Autor
Inda, María Carolina
Armando, Natalia Giannina
Dos Santos Claro, Paula Ayelen
Silberstein Cuña, Susana Iris
Resumen
Corticotropin-releasing hormone (CRH) is a key player of basal and stress activated responses in the hypothalamic-pituitary-adrenal axis (HPA) and in extrahypothalamic circuits, where it functions as a neuromodulator to orchestrate humoral and behavioral adaptive responses to stress. This review describes molecular components and cellular mechanisms involved in CRH signaling downstream of its G protein-coupled receptors (GPCRs) CRHR1 and CRHR2, and summarizes recent findings that challenge the classical view of GPCR signaling, and impact on our understanding of CRHRs function. Special emphasis is placed on recent studies of CRH signaling that revealed new mechanistic aspects of cAMP generation and ERK1/2 activation in physiologically relevant contexts of the neurohormone action. In addition, we present an overview of the pathophysiological role of the CRH system, which highlights the need for a precise definition of CRHRs signaling at molecular level to identify novel targets for pharmacological intervention in neuroendocrine tissues and specific brain areas involved in CRH-related disorders.