Buscar
Mostrando ítems 1-10 de 107
Pharmacological dose of alpha-tocopherol induces cardiotoxicity in Wistar rats determined by echocardiography and histology
(Sage Publications Ltd, 2011-10-01)
The effect of pharmacological dose of cc-tocopherol on heart health was determined in Wistar rats. Animals were randomly assigned to either C (control, n = II) or E (cc-tocopherol, n = II) group. Animals received corn oil ...
Biocompatible microemulsion modifies the pharmacokinetic profile and cardiotoxicity of doxorubicin
(2013-01-01)
Doxorubicin (DOX) is an anthracycline antibiotic with a broad antitumor spectrum. However, the clinical use of DOX is limited because of its cardiotoxicity, a dose-dependent effect. Colloidal drug delivery systems, such ...
Pamidronate Attenuates Oxidative Stress and Energetic Metabolism Changes but Worsens Functional Outcomes in Acute Doxorubicin-Induced Cardiotoxicity in Rats
(2016-12-01)
Background: Cardiotoxicity is the major side effect of doxorubicin. As mechanisms that are involved in cardiotoxicity are ambiguous, new methods for attenuating cardiotoxicity are needed. Recent studies have shown that ...
Cardiotoxicity of anticancer therapies. Towards the implementation of cardio-oncology units Cardiotoxicidad inducida por tratamientos oncológicos. Fundamentos para la implementación de equipos de Cardio-Oncología
(Sociedad Medica de Santiago, 2018)
© 2018, Sociedad Medica de Santiago. All rights reserved. Recently, we have witnessed major improvements in cancer treatment. Early diagnosis and development of new therapies have reduced cancer-related mortality. However, ...
Effects of pamidronate in acute cardiotoxicity induced by doxorubicin in rats
(2015)
Aim: Evaluate pamidronate (Pam) effects in ventricular function, matrix metalloproteinase-2 (MMP-2) activity, oxidative stress, and myocardial energetic metabolism during acute doxorubicin (Dox)-induced cardiotoxicity. ...
Acute doxorubicin-induced cardiotoxicity is associated with matrix metalloproteinase-2 alterations in rats
(Karger, 2015-01-01)
Background: Doxorubicin can cause cardiotoxicity. Matrix metalloproteinases (MMP) are responsible for degrading extracellular matrix components which play a role in ventricular dilation. Increased MMP activity occurs after ...
Effect of doxorubicin on cardiac lipid metabolism-related transcriptome and the protective activity of Alda-1
(Elsevier B.V., 2021-05-05)
The use of doxorubicin (DOX) as an antineoplastic drug is compromised by its cardiotoxicity risk. Although several mechanisms have been proposed for DOX-induced cardiac dysfunction, there is still increased interest in ...
Role of oxidative stress in the mechanisms of anthracyclineInduced cardiotoxicity: effects of preventive strategies
(Hindawi, 2021)
Anthracycline-induced cardiotoxicity (AIC) persists as a significant cause of morbidity and mortality in cancer survivors. Although many protective strategies have been evaluated, cardiotoxicity remains an ongoing threat. ...
Effect of different doses of 2,4-dichlorophenoxyacetic acid (2,4-d) on cardiac parameters in male Wistar rats
(2020-01-01)
The objective of this study was to evaluate the effects of different doses of 2,4-dichlorophenoxyacetic herbicide in rat hearts. Exposure was through rat food that was nebulized with the herbicide. Thirty adult male Wistar ...