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Synthesis of C-cinnamoyl glycosides and their inhibitory activity against mammalian carbonic anhydrases
(Elsevier, 2012-09)
A small series of C-cinnamoyl glycosides incorporating the phenol moiety has been prepared by reaction of glycosyl ketones with the appropriate benzaldehydes. Glycosides were tested for the inhibition of twelve mammalian ...
C-cinnamoyl glycosides: An emerging “Tail” for the development of selective carbonic anhydrase inhibitors
(Bentham Science Publishers, 2019-07)
Attachment of different tails to the well-known carbonic anhydrase (CA) pharma-cophores has led to the development of several new CA inhibitors (CAIs). A very good example of such “tails” is constituted by carbohydrates, ...
Topical carbonic anhydrase inhibitors in macular edema associated with Alstrom syndrome
(Taylor & Francis, 2016)
Background: Alstrom syndrome is a rare genetic ciliopathy caused by a mutation in the ALMS1 gene. The syndrome is characterized by cone-rod dystrophy, dilated myocardiopathy, childhood obesity and sensorineural hearing ...
Effect of carbonic anhydrase immobilized on eggshell membranes on calcium carbonate crystallization in vitro.
(2018)
The eggshell membranes (ESM) serve as the first interface with the inorganic phase during eggshell formation. During mineral growth, crystals nucleate on the outer side of the ESM at specialized sites called mammillae, ...
Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer
(Elsevier, 2013-03)
Targeting tumour associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms IX and XII is now considered as a pertinent approach for the development of new cancer therapeutics against hypoxic tumours. In the last period, with ...
Inhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety
(Taylor & Francis Ltd, 2015-11)
A small series of C-glycosides containing the phenol moiety was tested for the inhibition of the β-class carbonic anhydrases (βCAs, EC 4.2.1.1) from Brucella suis. Many compounds showed activities in the micromolar or ...
C-glycosides incorporating the 6-methoxy-2-naphthyl moiety are selective inhibitors of fungal and bacterial carbonic anhydrases
(Taylor & Francis, 2015-09)
A small series of C-glycosides containing the methoxyaryl moieties was tested for the inhibition of the β-class carbonic anhydrases (CAs, EC 4.2.1.1) from Cryptococcus neoformans and Brucella suis. Many compounds showed ...