info:eu-repo/semantics/article
Inhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety
Fecha
2015-11Registro en:
Riafrecha, Leonardo Ezequiel; Vullo, Daniela; Ouahrani Bettache, Safia; Köhler, Stephan; Dumy, Pascal; et al.; Inhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety; Taylor & Francis Ltd; Journal of Enzyme Inhibition and Medicinal Chemistry; 30; 6; 11-2015; 1017-1020
1475-6366
CONICET Digital
CONICET
Autor
Riafrecha, Leonardo Ezequiel
Vullo, Daniela
Ouahrani Bettache, Safia
Köhler, Stephan
Dumy, Pascal
Winum, Jean Yves
Supuran, Claudiu T.
Colinas, Pedro Alfonso
Resumen
A small series of C-glycosides containing the phenol moiety was tested for the inhibition of the β-class carbonic anhydrases (βCAs, EC 4.2.1.1) from Brucella suis. Many compounds showed activities in the micromolar or submicromolar range and excellent selectivity for pathogen CAs over human isozymes. Glycosides incorporating the 3-hydroxyphenyl moiety showed the best inhibition profile, and therefore this functionality represents lead for the development of novel anti-infectives with a new mechanism of action.