Articulo
C-glycosides incorporating the 6-methoxy-2-naphthyl moiety are selective inhibitors of fungal and bacterial carbonic anhydrases
Registro en:
issn:1475-6374
issn:1475-6366
Autor
Riafrecha, Leonardo Ezequiel
Vullo, Daniela
Supuran, Claudiu T.
Colinas, Pedro Alfonso
Institución
Resumen
A small series of C-glycosides containing the methoxyaryl moieties was tested for the inhibition of the β-class carbonic anhydrases (CAs, EC 4.2.1.1) from <i>Cryptococcus neoformans</i> and <i>Brucella suis</i>. Many compounds showed activities in the micromolar or submicromolar range and excellent selectivity for pathogen CAs over human isozymes. The deprotected glycosides incorporating the 6-methoxy-2-naphthyl moiety showed the best inhibition profile and therefore represent leads for the development of novel anti-infectives with a new mechanism of action. Facultad de Ciencias Exactas Laboratorio de Estudio de Compuestos Orgánicos