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Cys-loop receptors in Caenorhabditis elegans as pharmacological drug targets (Simposio)
(Fundación Revista Medicina, 2019)
The free-living nematode Caenorhabditis elegans has emerged as a powerful model for the study of the nervous system and human diseases and as a model for antiparasitic drug discovery. This nematode has also shown promise ...
Activation and modulation of the caenorhabditis elegans serotonin-gated chloride channel
(Fundación Revista Medicina, 2019)
Serotonin-gated ion channels (5-HT3) belong to the family of Cys-loop receptors, which are pentameric proteins that mediate fast synaptic transmission. In mammals, 5- HT3 are non-selective cationic channels that can be ...
A new antagonist of Caenorhabditis elegans glutamate-activated chloride channels with anthelmintic activity
(Sociedad Argentina de Investigación en Neurociencias, 2020)
Nematode parasitosis causes mortality and morbidity in humans and losses in livestock and domestic animals. The acquisition of resistance to current anthelmintic drugs has prompted the search for new compounds for which ...
Deciphering the molecular mechanisms underlying the anthelmintic effect of essential oils evaluated in Caenorhabditis elegans
(Genetics Society of America, 2021)
Helminths consist of a diverse group of parasitic worms including nematodes, which cause diseases of major socio-economic importance globally. Control of infections in both human and veterinary medicine currently relies ...
Caenorhabditis elegans serotonin-gated chloride channel MOD-1 as a novel drug target for anthelmintic therapy
(Sociedad Argentina de Biofísica, 2020)
Serotonin-gated ion channels (5-HT3) belong to the family of Cys-loop receptors, which are pentameric proteins that mediate fast synaptic transmission. In mammals, 5-HT3 are non-selective cationic channels that can be ...
Behavioral and molecular bases of the anthelmintic activity of essential oils explored in the nematode Caenorhabditis elegans
(Fundación Revista Medicina, 2021)
Control of helminth infections in both human and veterinary med icine currently relies mainly on chemotherapy, but acquisition of resistance is an increasing problem that leads to the urgent need of discovery of novel ...
Essential oils for the discovery of new anthelmintic compounds tested on the nematode Caenorhabditis Elegans
(Fundación Revista Medicina, 2020)
Parasitic nematodes of humans and animals cause dis- eases of major socio-economic importance globally. Con- trol of infections in both human and veterinary medicine currently relies mainly on chemotherapy, but resistance ...
A novel inhibitor of C. elegans glutamate-activated chloride channel with potential anthelmintic activity
(Fundación Revista Medicina, 2019)
Nematode parasitoses cause mortality and morbidity in humans and considerable losses in livestock, domestic animals and food crops. The acquisition of resistance to current anthelmintic drugs has prompted the search for ...
A new antagonist of Caenorhabditis elegans glutamate-activated chloride channels with anthelmintic activity
(Sociedad Argentina de Biofísica, 2020)
Diisopropylphenyl-imidazole (DII): a new compound that exerts anthelmintic activity through novel molecular mechanisms
(Fundación Revista Medicina, 2019)
Nematode parasites cause infections that affect approximately one-third of the world ́s population and considerable losses in livestock and food crops. Paradoxically, the repertoire of effective anthelmintics for treating ...