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Culturing bacteria from caenorhabditis elegans gut to assess colonization proficiency
(Bio-Protocol, 2017-06)
Determining an accurate count of intestinal bacteria from Caenorhabditis elegans is onecritical way to assess colonization proficiency by a given bacteria. This can be accomplished by culturingappropriate dilutions of worm ...
Circadian rhythms in metabolic variables in Caenorhabditis elegans
(Pergamon-Elsevier Science Ltd, 2011-06)
Circadian rhythms govern a wide variety of physiological and metabolic functions in most organisms through neural networks, hormones and gene expression. In this work, we studied the circadian variation in metabolic variables ...
Cys-loop receptors in Caenorhabditis elegans as pharmacological drug targets (Simposio)
(Fundación Revista Medicina, 2019)
The free-living nematode Caenorhabditis elegans has emerged as a powerful model for the study of the nervous system and human diseases and as a model for antiparasitic drug discovery. This nematode has also shown promise ...
Activation of Caenorhabditis elegans Levamisole-Sensitive and Mammalian Nicotinic Receptors by the Antiparasitic Bephenium
(American Society for Pharmacology and Experimental Therapeutics, 2018-11)
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels involved in neuromuscular transmission. In nematodes, muscle nAChRs are targets of antiparasitic drugs. Bephenium is an anthelmintic compound whose ...
Activation and modulation of the caenorhabditis elegans serotonin-gated chloride channel
(Fundación Revista Medicina, 2019)
Serotonin-gated ion channels (5-HT3) belong to the family of Cys-loop receptors, which are pentameric proteins that mediate fast synaptic transmission. In mammals, 5- HT3 are non-selective cationic channels that can be ...
Combining single-cell RNA-sequencing with a molecular atlas unveils new markers for Caenorhabditis elegans neuron classes
(Oxford University Press, 2020-06)
Single-cell RNA-sequencing (scRNA-seq) of the Caenorhabditis elegans nervous system offers the unique opportunity to obtain a partial expression profile for each neuron within a known connectome. Building on recent scRNA-seq ...
A new antagonist of Caenorhabditis elegans glutamate-activated chloride channels with anthelmintic activity
(Sociedad Argentina de Investigación en Neurociencias, 2020)
Nematode parasitosis causes mortality and morbidity in humans and losses in livestock and domestic animals. The acquisition of resistance to current anthelmintic drugs has prompted the search for new compounds for which ...
Endocannabinoids in Caenorhabditis elegans are essential for the mobilization of cholesterol from internal reserves
(Nature Publishing Group, 2018-12)
Proper cholesterol transport is crucial for the functionality of cells. In C. elegans, certain cholesterol derivatives called dafachronic acids (DAs) govern the entry into diapause. In their absence, worms form a developmentally ...
Bacillus subtilis biofilm extends Caenorhabditis elegans longevity through downregulation of the insulin-like signalling pathway
(Nature Publishing Group, 2017-01)
Beneficial bacteria have been shown to affect host longevity, but the molecular mechanisms mediating such effects remain largely unclear. Here we show that formation of Bacillus subtilis biofilms increases Caenorhabditis ...
Drug discovery: Insights from the invertebrate Caenorhabditis elegans
(John Wiley & Sons Ltd, 2021-04-09)
Therapeutic drug development is a long, expensive, and complex process that usually takes 12–15 years. In the early phases of drug discovery, in particular, there is a growing need for animal models that ensure the reduction ...