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Screening of transcription factors involved in fetal hemoglobin regulation using phylogenetic footprinting
(2015-10-27)
Fetal hemoglobin (Hb F) is an important genetic modulator of the beta-hemoglobinopathies. The regulation of Hb F levels is influenced by transcription factors. We used phylogenetic footprinting to screen transcription ...
Expression of COUP-TFII Nuclear Receptor in Restricted GABAergic Neuronal Populations in the Adult Rat Hippocampus
(SOC NEUROSCIENCE, 2010)
The COUP-TFII nuclear receptor, also known as NR2F2, is expressed in the developing ventral telencephalon and modulates the tangential migration of a set of subpallial neuronal progenitors during forebrain development. ...
P450Arom induction in isolated control endometrial cells by peritoneal fluid from women with endometriosis
(2010)
Objective: To study the effect of peritoneal fluid from women with (PF-E) and without (PF-C) endometriosis on
P450Arom expression in endometrial cells.
Design: Experimental study.
Setting: University research ...
Crosstalk of BMP-4 and RA signaling pathways on Pomc gene regulation in corticotrophs
(BioScientifica, 2019-10)
Retinoic acid (RA), an active metabolite of Vitamin A, and bone morphogenetic protein 4 (BMP-4) pathways control the transcription of pro-opiomelanocortin (Pomc), the precursor of ACTH. We describe a novel mechanism by ...
New Insights in Cushing Disease Treatment With Focus on a Derivative of Vitamin A
(Frontiers Research Foundation, 2018-05)
Cushing's disease (CD) is an endocrine disorder originated by a corticotroph tumor. It is linked with high mortality and morbidity due to chronic hypercortisolism. Treatment goals are to control cortisol excess and achieve ...