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Chasing coevolutionary signals in intrinsically disordered proteins complexes
(Nature, 2020-10)
Intrinsically disordered proteins/regions (IDPs/IDRs) are crucial components of the cell, they are highly abundant and participate ubiquitously in a wide range of biological functions, such as regulatory processes and cell ...
The role of protein disorder in the 14-3-3 interaction network
(Royal Society of Chemistry, 2012-11)
Disordered regions are segments of a protein that do not fold completely and thus remain flexible. These regions have key physiological roles, particularly in phospho-proteins, which are enriched in disorder-promoting ...
Statistical complexity of the coriolis antipairing effect
(Molecular Diversity Preservation International, 2019-06)
Using the entropic quantifier called statistical complexity, we investigate the interplay between (1) pairing interactions between fermions, can be viewed as analogous with superconductivity based on Cooper pairs; (2) ...
Gliadin proteolytical resistant peptides: the interplay between structure and self-assembly in gluten-related disorders
(Springer, 2021-12)
In recent years, the evaluation of the structural properties of food has become of crucial importance in the understanding of food-related disorders. One of the most exciting systems is gliadin, a protein in wheat gluten, ...
Dysregulation of Neuronal Nicotinic Acetylcholine Receptor-Cholesterol Crosstalk in Autism Spectrum Disorder
(Frontiers Media, 2021-10)
Autism spectrum disorder (ASD) is a set of complex neurodevelopmental diseases that include impaired social interaction, delayed and disordered language, repetitive or stereotypic behavior, restricted range of interests, ...
Controlling distant contacts to reduce disease spreading on disordered complex networks
(Elsevier Science, 2020-05)
In real social networks, person-to-person interactions are known to be heterogeneous, which can affect the way a disease spreads through a population, reaches a tipping point in the fraction of infected individuals, and ...
Ensembles from Ordered and Disordered Proteins Reveal Similar Structural Constraints during Evolution
(Academic Press Ltd - Elsevier Science Ltd, 2019-03-15)
The conformations accessible to proteins are determined by the inter-residue interactions between amino acid residues. During evolution, structural constraints that are required for protein function providing biologically ...
Solid-state structures and thermal properties of inclusion complexes of the organophosphate insecticide fenitrothion with permethylated cyclodextrins
(Elsevier, 2010-01)
The X-ray crystal structures and thermal stabilities of the inclusion complexes formed between the organophosphate insecticide fenitrothion [O,O-dimethyl O-(3-methyl-4-nitrophenyl) phosphorothioate] and the host compounds ...
Neuroimmune and inflammatory signals in complex disorders of the central nervous system
(Karger, 2019-02)
An extensive microglial-astrocyte-monocyte-neuronal cross talk seems to be crucial for normal brain function, development, and recovery. However, under certain conditions neuroinflammatory interactions between brain cells ...
Insight into membraneless organelles and their associated proteins: Drivers, Clients and Regulators
(Elsevier, 2021-06)
In recent years, attention has been devoted to proteins forming immiscible liquid phases within the liquid intracellular medium, commonly referred to as membraneless organelles (MLO). These organelles enable the spatiotemporal ...