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Central ceramide signaling mediates obesity-induced precocious puberty
(Cell, 2020)
Childhood obesity, especially in girls, is frequently bound to earlier puberty, which is linked to higher disease burden later in life. The mechanisms underlying this association remain elusive. Here we show that brain ...
Papel de las células NKT invariantes en la respuesta inmune anti-viral.
(2013-09-24)
Las células T asesinas naturales con receptor de células T invariante y restringidas por la molécula CD1d (iNKT) son un subgrupo
de linfocitos con potente actividad inmunorreguladora; su respuesta casi inmediata y la ...
Calcium & ROS: two orchestra directors for the requiem of death
(Elsevier, 2020)
Tumor necrosis factor alpha (TNF) triggers regulated necrosis of mycobacterium-infected macrophages through of mitochondrial reactive oxygen species (mitoROS) production in a RIPK1/3-dependent manner. To explain that, Roca ...
Possible role of sulphatide in the K+-activated phosphatase activity
(1983)
A microsomal fraction rich in (Na+ + K+)-ATPase has been isolated from the outer medulla of pig kidney. (Mg2+ + K+)-activated ouabain-sensitive phosphatase activity was studied in this preparation treated with arylsulphatase, ...
Trimetazidine prevents palmitate-induced mitochondrial fission and dysfunction in cultured cardiomyocytes
(Elsevier Inc., 2014)
© 2014 Elsevier Inc. All rights reserved. Metabolic and cardiovascular disease patients have increased plasma levels of lipids and, specifically, of palmitate, which can be toxic for several tissues. Trimetazidine (TMZ), ...
Metachromatic leukodystrophy: Diagnosis and treatment challenges
(Ecuador, 2021-06-03)
Metachromatic leukodystrophy is a neurological disease of the lysosomal deposit that has a significant impact given the implications for the neurodegenerative deterioration of the patient. Currently, there is no treatment ...
Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells
(Elsevier, 2015)
A considerable body of evidence exists implicating high levels of free saturated fatty acids in beta pancreatic cell
death, although the molecular mechanisms and the signaling pathways involved have not been clearly ...
Decreased invariant natural killer T-cell-mediated antitumor immune response in patients with gastric cancer
(Wiley, 2020)
Gastric cancer (GC) is the third most common cause of cancer-related death worldwide. Invariant natural killer T (iNKT) cells are innate-like cytotoxic T lymphocytes involved in tumor immune surveillance. They can be ...
PRONÓSTICO DE LA DEMANDA MENSUAL DE ELECTRICIDAD CON SERIES DE TIEMPO
(Fondo Editorial EIA - Universidad EIA, 2017-03-05)
Objetivo: Implementar modelos con series de tiempo para el pronóstico de la demanda mensual de electricidad (Gwh).Materiales y Métodos: Para el desarrollo y validación de los modelos se tomaron como base los valores de la ...