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CD8 + T cell immunity Is compromised by Anti-CD20 treatment and rescued by Interleukin-17A
(ASM, 2020-05)
Treatment with anti-CD20, used in many diseases in which B cells play a pathogenic role, has been associated with susceptibility to intracellular infections. Here, we studied the effect of anti-CD20 injection on CD8+ T ...
NK cells restrain spontaneous antitumor CD8+ T cell priming through pd-1/pd-l1 interactions with dendritic cells
(American Association of Immunologists, 2016-08)
Despite the classical function of NK cells in the elimination of tumor and of virus-infected cells, evidence for a regulatory role for NK cells has been emerging in different models of autoimmunity, transplantation, and ...
Trypanosoma cruzi Induces Regulatory B Cell Alterations in Patients With Chronic Chagas Disease
(Frontiers Media, 2021-08)
The clinical evolution of patients with chronic Chagas disease (CCD) is mainly associated with an excessive inflammation and a defective immunomodulatory profile caused by the interaction between T. cruzi and the host. ...
Ex vivo characterization of Breg cells in patients with chronic Chagas disease
(Nature, 2021-03-09)
Despite the growing importance of the regulatory function of B cells in many infectious diseases, their immunosuppressive role remains elusive in chronic Chagas disease (CCD). Here, we studied the proportion of different ...
A Systematic, Unbiased Mapping of CD8+ and CD4+ T Cell Epitopes in Yellow Fever Vaccinees
(Frontiers Media S.A., 2020-08)
Examining CD8+ and CD4+ T cell responses after primary Yellow Fever vaccination in a cohort of 210 volunteers, we have identified and tetramer-validated 92 CD8+ and 50 CD4+ T cell epitopes, many inducing strong and prevalent ...
HIV–TB coinfection impairs CD8+ T‐cell differentiation and function while dehydroepiandrosterone improves cytotoxic antitubercular immune responses
(Wiley VCH Verlag, 2015-06)
Tuberculosis (TB) is the leading cause of death among HIV-positive patients. The decreasing frequencies of terminal effector (TTE ) CD8+ T cells may increase reactivation risk in persons latently infected with Mycobacterium ...
High RAC3 expression levels are required for induction and maintaining of cancer cell stemness
(Impact Journals, 2017-12)
RAC3 is a transcription coactivator, usually overexpressed in several tumors and required to maintain the pluripotency in normal stem cells. In this work we studied the association between RAC3 overexpression on cancer ...
B cells from patients with rheumatoid arthritis show conserved CD39-mediated regulatory function and increased CD39 expression after positive response to therapy
(Academic Press Ltd - Elsevier Science Ltd, 2021-01)
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by progressive joint destruction associated with increased pro-inflammatory mediators. In inflammatory microenvironments, exogenous ATP (eATP) is ...
Hypoxia supports differentiation of terminally exhausted CD8 T cells
(Frontiers Media S.A., 2021-05)
Hypoxia, angiogenesis, and immunosuppression have been proposed to be interrelated events that fuel tumor progression and impair the clinical effectiveness of anti-tumor therapies. Here we present new mechanistic data ...
In vitro susceptibility of CD4+ and CD8+ T cell subsets to fludarabine
(Pergamon-Elsevier Science Ltd, 2003-12)
Administration of the adenosine analogue fludarabine (FLU) in vivo induces a profound and prolonged T lymphopenia which mainly affects CD4+ cells. To better understand the mechanistic basis underlying this preferential ...