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CD8 + T cell immunity Is compromised by Anti-CD20 treatment and rescued by Interleukin-17A
(ASM, 2020-05)
Treatment with anti-CD20, used in many diseases in which B cells play a pathogenic role, has been associated with susceptibility to intracellular infections. Here, we studied the effect of anti-CD20 injection on CD8+ T ...
HLA-DR marks recently divided antigen-specific effector CD4 T cells in active tuberculosis patients
(American Association of Immunologists, 2021)
Upon Ag encounter, T cells can rapidly divide and form an effector population, which plays an important role in fighting acute infections. In humans, little is known about the molecular markers that distinguish such effector ...
NK cells restrain spontaneous antitumor CD8+ T cell priming through pd-1/pd-l1 interactions with dendritic cells
(American Association of Immunologists, 2016-08)
Despite the classical function of NK cells in the elimination of tumor and of virus-infected cells, evidence for a regulatory role for NK cells has been emerging in different models of autoimmunity, transplantation, and ...
CD4+ T cell subsets and Tax expression in HTLV-1 associated diseases
(Taylor and Francis, 2013)
Human T lymphotropic virus type 1 (HTLV-1) infection displays variable clinical manifestations. These include inflammatory diseases such as HTLV-1 associated myelopathy (HAM) or immunosuppressive conditions such as ...
Identification and culture of proliferative cells in abnormal Taenia solium larvae: Role in the development of racemose neurocysticercosis
(Public Library of Science, 2021)
Racemose neurocysticercosis is an aggressive disease caused by the aberrant expansion of the cyst form of Taenia solium within the subarachnoid spaces of the human brain and spinal cord resulting in a mass effect and ...
Trypanosoma cruzi Induces Regulatory B Cell Alterations in Patients With Chronic Chagas Disease
(Frontiers Media, 2021-08)
The clinical evolution of patients with chronic Chagas disease (CCD) is mainly associated with an excessive inflammation and a defective immunomodulatory profile caused by the interaction between T. cruzi and the host. ...
CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis
(BioMed Central, 2014)
Background: Human T-cell lymphotropic virus (HTLV-1) is the causative agent of the incapacitating, neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Currently, there are no ...
Ex vivo characterization of Breg cells in patients with chronic Chagas disease
(Nature, 2021-03-09)
Despite the growing importance of the regulatory function of B cells in many infectious diseases, their immunosuppressive role remains elusive in chronic Chagas disease (CCD). Here, we studied the proportion of different ...
A Systematic, Unbiased Mapping of CD8+ and CD4+ T Cell Epitopes in Yellow Fever Vaccinees
(Frontiers Media S.A., 2020-08)
Examining CD8+ and CD4+ T cell responses after primary Yellow Fever vaccination in a cohort of 210 volunteers, we have identified and tetramer-validated 92 CD8+ and 50 CD4+ T cell epitopes, many inducing strong and prevalent ...
HIV–TB coinfection impairs CD8+ T‐cell differentiation and function while dehydroepiandrosterone improves cytotoxic antitubercular immune responses
(Wiley VCH Verlag, 2015-06)
Tuberculosis (TB) is the leading cause of death among HIV-positive patients. The decreasing frequencies of terminal effector (TTE ) CD8+ T cells may increase reactivation risk in persons latently infected with Mycobacterium ...