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Activation of the lytic program of the Epstein–Barr virus in Burkitt's lymphoma cells leads to a two steps downregulation of expression of the proapoptotic protein BimEL, one of which is EBV-late-gene expression dependent
(Virology 387 (2009) (1) p.41.49, 2009-02-28)
The Epstein–Barr virus (EBV) generally latently infects its target cells with expression of genes conferring resistance to apoptosis. However, the modulation of apoptotic signals during lytic cycle remains poorly understood. ...
Phosphatidylinositol 3-Kinase/Akt Pathway Targets Acetylation of Smad3 through Smad3/CREB-binding Protein Interaction: Contribution to transforming growth factor 1-induced epstein-barr virus reactivation
(THE JOURNAL OF BIOLOGICAL CHEMISTRY 284(36), pp. 23912–23924, 2009-09-04)
Epstein-Barr virus, a ubiquitous human herpesvirus, is associated with the development of carcinomas and lymphomas. We previously showed that transforming growth factor 1 (TGF- 1) mediated the virus to enter the lytic ...
Methylmercury increases S100B content in rat cerebrospinal fluid
(2005-02)
S100B, a calcium binding protein physiologically produced and released by astrocytes, has been used as a peripheral marker of brain damage. Here, we investigated the effects of subcutaneous injections of methylmercury ...
Myotoxin II from Bothrops asper (Terciopelo) venom is a lysine-49 phospholipase A2
(1991)
A basic, dimeric myotoxic protein, myotoxin II, purified from Bothrops asper venom has a similar molecular weight and is immunologically cross-reactive with antibodies raised to previously isolated B. asper phospholipases ...
Electrophoretic and immunochemical studies of Micrurus venoms
(1994)
The electrophoretic mobilities of venom components from 15 Micrurus species were studied by polyacrylamide gel electrophoresis. The venoms showed species-specific protein patterns under native (PAGE) or denaturing (urea-PAGE) ...
Antivenomic Assessment of the Immunological Reactivity of EchiTAb-Plus-ICP, an Antivenom for the Treatment of Snakebite Envenoming in Sub-Saharan Africa
(2010)
The immunoreactivity of EchiTAb-Plus-ICP, an antivenom developed for the treatment of snakebite envenoming in sub-Saharan Africa, to venoms of seven Echis and Bitis species, was assessed by “antivenomics.” This proteomic ...
South American snake venom proteins antigenically-related to Bothrops asper myotoxins.
(1990)
the presence of proteins antigenically related to Bothrops asper myotoxins in various snake venoms, mainly from South America, was investigated by using poluclonal and monoclonal antibodies. 2. Myotoxin-like components ...
Cross-recognition of a pit viper (Crotalinae) polyspecific antivenom explored through high-density peptide microarray epitope mapping
(2017-07)
Snakebite antivenom is a 120 years old invention based on polyclonal mixtures of antibodies
purified from the blood of hyper-immunized animals. Knowledge on antibody recognition
sites (epitopes) on snake venom proteins ...
Acute-phase reactions, including cytokines, in patients bitten by Bothrops and Crotalus snakes in Brazil
(1995)
Thirty-one patients bitten by venomous snakes in Botucatu area (State of São
Paulo - Brazil), sixteen by Bothrops spp. and fifteen by Crotalus durissus terrificus, were
studied. The group comprised twenty-nine males and ...
Venom, venomics, antivenomics
(2009)
Venoms comprise mixtures of peptides and proteins tailored by Natural Selection to act on vital systems
of the prey or victim. Here we review our proteomic protocols for uncoiling the composition,
immunological profile, ...