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Brain-to-Plasma Concentration Ratio and Unbound Partition Coefficient
(Springer Nature Switzerland AG, 2021)
The brain-to-plasma concentration ratio (or totalbrain-to-plasma ratio, or simply, brain-to-plasma ratio, Kp, also referred toas B/P ratio or BB) is, as suggested by the name, the ratio between the total(bound and unbound) ...
Bioavailability of butorphanol after intranasal administration to horses
(Trakia University, 2020-12)
The aim of the present study was to describe butorphanol pharmacokinetics and bioavailability following intranasal administration to horses. Six adult horses received 0.05 mg/kg butorphanol, in a randomised crossover design, ...
Impact of water hardness on oxytetracycline oral bioavailability in fed and fasted piglets
(Wiley Blackwell Publishing, Inc, 2019-07)
Water hardness is a critical factor that affects oxytetracycline dissolution by chelation with cations. These interactions may lead to impaired dosing and consequently decrease absorption. Moreover, feed present in ...
Effect of genotype and sex of the host on the bioavailability of novel albendazole microcrystals based on chitosan and cellulose derivatives
(Springer, 2020-05)
Albendazole (ABZ), an anthelmintic compound widely used in the treatment of systemic nematode infections, is included in the list of class II drugs based on the Biopharmaceutical Classification System. ABZ has limited ...
The use of saliva as a biological fluid in relative bioavailability studies: Comparison and correlation with plasma results
(John Wiley & Sons Ltd, 2010-11)
The aim of the present study was to present new evidence supporting the use of saliva as a biological fluid in relative bioavailability studies. Carbamazepine was chosen as a model drug because of its suitability for ...
Potential interactions between an oral fosfomycin formulation and feed or drinking water: Impact on bioavailability in piglets
(Wiley Blackwell Publishing, Inc, 2021-03)
Feed and drinking water are the most frequently used vehicles for administration of antibiotics in intensive pig production. Interactions of drugs with feed and water components may affect dissolution and bioavailability. ...
Enhanced intestinal permeability and oral bioavailability of enalapril maleate upon complexation with the cationic polymethacrylate Eudragit E100
(Elsevier Science, 2014-05)
The low bioavailability of enalapril maleate associated to its instability in solid state motivated the development of a polyelectrolyte-drug complex between enalapril maleate and the cationic polymethacrylate Eudragit ...
Minerals
(Elsevier, 2017)
Essential minerals must be incorporated through the diet. They have manyfunctions in the body and if not provided in sufficient amounts, deficienciesare manifested through specific and nonspecific symptoms. However the ...
Toxicity and bioavailability of mercury in spiked sediments on Hyalella curvispina Shoemaker, 1942
(Inderscience Enterprises, 2013)