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Retinoic acid reduces migration of human breast cancer cells: role of retinoic acid receptor beta
(Wiley, 2014-01)
Breast cancer is the most common malignancy in women and the appearance of distant metastases produces the death in 98% of cases. The retinoic acid receptor b (RARb) is not expressed in 50% of invasive breast carcinoma ...
Downregulation of beta adrenergic receptor expression on B cells by activation of early signals in alloantigen-induced immune response
(Karger, 2000-12)
Previously we described a decrease in β-adrenergic receptor expression in B lymphocytes as a consequence of in vivo alloimmunization. This decrease correlates with the highest response of alloantibody production by B cells. ...
Therapeutics utilizing cell-based interventions for type 1 diabetes mellitus
(Wiley, 2013-02)
Type 1 diabetes mellitus (T1DM) results from death of insulin-secreting β cells mediated by self-immune cells, and the consequent inability of the body to maintain insulin levels for appropriate glucose homeostasis. Probably ...
Beta cell adaptation/dysfunction in an animal model of dyslipidemia and insulin resistance induced by the chronic administration of a sucrose-rich diet
(Landes Bioscience Journal, 2010-11)
Glucose stimulated insulin secretion (GSIS) was different in rats chronically fed a sucrose-rich diet (SRD) for 3 or 30 wk. This work proposes possible mechanisms underlying insulin secretion changes from â-cell throughout ...
Perinatal DEHP exposure modulates pituitary estrogen receptor α and β expression altering lactotroph and somatotroph cell growth in prepuberal and adult male rats
(Pergamon-Elsevier Science Ltd, 2021-12)
Phthalates are synthetic chemicals widely used to make polyvinylchloride (PVC) soft and flexible. Of these, Di-(2-ethylhexyl) phthalate (DEHP) is the most commonly used, with high human exposure occurring as early as the ...
Interleukin-1ß regulates nitric oxide production and gamma-glutamyltranspeptidase activity in Sertoli cells
(American Society of Andrology, 2000-12)
Several cytokines have been involved in the regulation of Sertoli cell function. Further investigations are required to elucidate the role of interleukin-1beta (IL1beta) in Sertoli cell physiology. Twenty-day-old rat ...