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Retinoic acid reduces migration of human breast cancer cells: role of retinoic acid receptor beta
(Wiley, 2014-01)
Breast cancer is the most common malignancy in women and the appearance of distant metastases produces the death in 98% of cases. The retinoic acid receptor b (RARb) is not expressed in 50% of invasive breast carcinoma ...
Downregulation of beta adrenergic receptor expression on B cells by activation of early signals in alloantigen-induced immune response
(Karger, 2000-12)
Previously we described a decrease in β-adrenergic receptor expression in B lymphocytes as a consequence of in vivo alloimmunization. This decrease correlates with the highest response of alloantibody production by B cells. ...
Therapeutics utilizing cell-based interventions for type 1 diabetes mellitus
(Wiley, 2013-02)
Type 1 diabetes mellitus (T1DM) results from death of insulin-secreting β cells mediated by self-immune cells, and the consequent inability of the body to maintain insulin levels for appropriate glucose homeostasis. Probably ...
Beta cell adaptation/dysfunction in an animal model of dyslipidemia and insulin resistance induced by the chronic administration of a sucrose-rich diet
(Landes Bioscience Journal, 2010-11)
Glucose stimulated insulin secretion (GSIS) was different in rats chronically fed a sucrose-rich diet (SRD) for 3 or 30 wk. This work proposes possible mechanisms underlying insulin secretion changes from â-cell throughout ...
Perinatal DEHP exposure modulates pituitary estrogen receptor α and β expression altering lactotroph and somatotroph cell growth in prepuberal and adult male rats
(Pergamon-Elsevier Science Ltd, 2021-12)
Phthalates are synthetic chemicals widely used to make polyvinylchloride (PVC) soft and flexible. Of these, Di-(2-ethylhexyl) phthalate (DEHP) is the most commonly used, with high human exposure occurring as early as the ...
Interleukin-1ß regulates nitric oxide production and gamma-glutamyltranspeptidase activity in Sertoli cells
(American Society of Andrology, 2000-12)
Several cytokines have been involved in the regulation of Sertoli cell function. Further investigations are required to elucidate the role of interleukin-1beta (IL1beta) in Sertoli cell physiology. Twenty-day-old rat ...
Participation of HSP27 in the antiapoptotic action of 17β-estradiol in skeletal muscle cells
(Springer, 2010-03)
Exposure to 17β-estradiol prior to induction of apoptosis protects skeletal muscle cells against damage. The mechanism involved in this protective action of the hormone is poorly understood. In the present study, using the ...
Progestin activation of nongenomic pathways via cross talk of progesterone receptor with estrogen receptor beta induces proliferation of endometrial stromal cells
(Endocrine Society, 2005-12)
Uterine decidualization is characterized by stromal cell proliferation and differentiation, which are controlled by ovarian hormones estradiol and progesterone. Here we report that the proliferative response of UIII rat ...