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Isolation and characterization of a novel metalloprotease inhibitor from Bothrops alternatus snake serum
(2017-05-01)
Resistance of snakes and some other animals to snake envenomation has been attributed to soluble factors present in their tissues. Here we report the isolation of a novel metalloprotease inhibitor from Bothrops alternatus ...
rBaltMIP, a recombinant alpha-type myotoxin inhibitor from Bothrops alternatus (Rhinocerophis alternatus) snake, as a potential candidate to complement the antivenom therapy
(Elsevier B.V., 2016-12-15)
Phospholipase A(2) inhibitors (PLIs) are important targets in the search and development of new drugs. This study aimed at evaluating the potential of an alpha-type phospholipase A(2) inhibitor from Bothrops alternatus ...
Bronchus-Associated Lymphoid Tissue (BALT) and Survival in a Vaccine Mouse Model of Tularemia
(PUBLIC LIBRARY SCIENCE, 2010)
Background: Francisella tularensis causes severe pulmonary disease, and nasal vaccination could be the ideal measure to effectively prevent it. Nevertheless, the efficacy of this type of vaccine is influenced by the lack ...
BaltPLA 2 : A new phospholipase A 2 from Bothrops alternatus snake venom with antiplatelet aggregation activity
(2018-01-01)
Background: In last decades, snake venoms have aroused great interest of the medicine due to the pathophysiological effects caused by their toxins. These include the phospholipases A 2 , low molecular weight proteins capable ...
Heterologous expression and biochemical and functional characterization of a recombinant alpha-type myotoxin inhibitor from Bothrops alternatus snake
(Elsevier B.V., 2014-10-01)
Venomous and non-venomous snakes possess phospholipase A(2) (PLA(2)) inhibitory proteins (PLIs) in their blood serum. This study shows the expression and biochemical and functional characterization of a recombinant alpha ...
Centimetre-wave continuum radiation from the rho Ophiuchi molecular cloud
(BLACKWELL PUBLISHING, 2008-12-11)
The rho Oph molecular cloud is undergoing intermediate-mass star formation. Ultraviolet radiation from its hottest young stars heats and dissociates exposed layers, but does not ionize hydrogen. Only faint radiation from ...
Neutralization of pharmacological and toxic activities of Bothrops snake venoms by Schizolobium parahyba (Fabaceae) aqueous extract and its fractions
(WILEY-BLACKWELL, 2008)
The aqueous extract prepared from Schizolobium parahyba (Sp) leaves, a native plant from Atlantic Forest (Brazil), was tested to analyse its ability to inhibit some biological and enzymatic activities induced by Bothrops ...
Platelet aggregation and antibacterial effects of an L-amino acid oxidase purified from Bothrops alternatus snake venom
(Elsevier B.V., 2004-06-01)
The isolation and biochemical/enzymatic characterization of an L-amino acid oxidase, Balt-LAAO-I, from Bothrops alternates snake venom, is described. Balt-LAAO-I is an acidic glycoprotein, pI similar to 5.37, homodimeric, ...