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In vitro methods to study the modulation of migration and invasion by sphingosine-1-phosphate
(Humana Press, 2017-04)
Sphingosine-1-phosphate (S1P) is a bioactive lipid that modulates migratory behavior of cells during embryonic development. In addition, S1P might promote tumor progression by enhancing migratory ability and invasiveness ...
Quercetin Reduces Neutrophil Recruitment Induced by CXCL8, LTB(4), and fMLP: Inhibition of Actin Polymerization
(AMER CHEMICAL SOC, 2011)
Recent in vitro data have suggested that the flavonoid quercetin (1) does not affect the functioning of neutrophils. Therefore, we evaluated in vivo and in vitro whether or not 1 affects neutrophil function, focusing on ...
Synthesis of the Macrolactone of Migrastatin and Analogues with Potent Cell-Migration Inhibitory Activity
(WILEY-BLACKWELL, 2010)
The synthesis of the macrolactone core of migrastatin 2, its potent anti-metastasis analogue 34, and ester derivatives 35 and 38 are reported. The approach involves the use of a dihydroxylation reaction to establish the ...
Synthesis, electrochemical studies and anticancer activity of ferrocenyl oxindoles
(Royal Society of Chemistry - RSCCambridge, 2010)
A series of (E) and (Z)-ferrocenyl oxindoles were prepared by coupling substituted oxindoles to ferrocenylcarboxyaldehyde in the presence of morpholine as a catalyst. The redox behavior of these isomers was determined by ...
Synthesis of the macrolactone of migrastatin and analogues with potent cell-migration inhibitory activity
(Wiley-VCH VerlagWeinheim, 2010-12)
The synthesis of the macrolactone core of migrastatin 2, its potent anti-metastasis analogue 34, and ester derivatives 35 and 38 are reported. The approach involves the use of a dihydroxylation reaction to establish the ...
Synthesis, electrochemical studies and anticancer activity of ferrocenyl oxindoles
(ROYAL SOC CHEMISTRY, 2010)
A series of (E) and (Z)-ferrocenyl oxindoles were prepared by coupling substituted oxindoles to ferrocenylcarboxyaldehyde in the presence of morpholine as a catalyst. The redox behavior of these isomers was determined by ...
Synthetic analogue of the natural product piperlongumine as a potent inhibitor of breast cancer cell line migration
(2017-03-01)
Piperlongumine is a natural amide alkaloid isolated from several species of Piper and is described in the literature as selectively cytotoxic to several cancer cell lines. Inhibiting cell migration has gained considerable ...
Laminin-derived peptide AG73 regulates migration, invasion, and protease activity of human oral squamous cell carcinoma cells through syndecan-1 and beta 1 integrin
(SPRINGER, 2010)
Squamous cell carcinoma is a prevalent head and neck tumor with high mortality. We studied the role played by laminin alpha 1 chain peptide AG73 on migration, invasion, and protease activity of cells (OSCC) from human oral ...
Nubbe natural products, source of molecular diversity for the design of new anticancer agents
(Universidade Estadual Paulista (Unesp), 2014-03-28)
Natural products are an important source for the design of new drugs. This thesis aimed at the identification of bioactive natural products to be used as models for the design of compounds with antitumor properties. The ...
Nubbe natural products, source of molecular diversity for the design of new anticancer agents
(Universidade Estadual Paulista (UNESP), 2014)