Artículos de revistas
Synthesis, electrochemical studies and anticancer activity of ferrocenyl oxindoles
Fecha
2010Registro en:
Dalton Transactions,Cambridge : Royal Society of Chemistry - RSC,v. 39, n. 31, p. 7338-7344, 2010
1477-9226
10.1039/c002983a
Autor
Silva, Bárbara V.
Ribeiro, Núbia M.
Vargas, Maria D.
Lanznaster, Maurício
Carneiro, José Walkimar M.
Krogh, Renata
Andricopulo, Adriano Defini
Dias, Luiz C.
Pinto, Angelo C.
Institución
Resumen
A series of (E) and (Z)-ferrocenyl oxindoles were prepared by coupling substituted oxindoles to ferrocenylcarboxyaldehyde in the presence of morpholine as a catalyst. The redox behavior of these isomers was determined by cyclic voltammetry. The effects of the oxindole derivatives on the migration of human breast cancer cells were evaluated using the wound-healing assay and the Boyden chamber cell-migration assay. The most potent Z isomers 11b (IC50 = 0.89 μM), 12b (IC50 = 0.49 μM) and 17b (IC50 = 0.64 μM) could represent attractive new lead compounds for further development for cancer therapy.