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Kinesin-1-mediated axonal transport of CB1 receptors is required for cannabinoid-dependent axonal growth and guidance
(Company of Biologists, 2020-04)
Endocannabinoids (eCB) modulate growth cone dynamics and axonal pathfinding through the stimulation of cannabinoid type-1 receptors (CB1R), the function of which depends on their delivery and precise presentation at the ...
New insights on epigenetic mechanisms supporting axonal development: Histone marks and miRNAs
(Wiley Blackwell Publishing, Inc, 2020-12)
Mechanisms supporting axon growth and the establishment of neuronal polarity have remained largely disconnected from their genetic and epigenetic fundamentals. Recently, post-transcriptional modifications of histones ...
Positional differences of axon growth rates between sensory neurons encoded by runx3
(Nature Publishing Group, 2012-09)
The formation of functional connectivity in the nervous system is governed by axon guidance that instructs nerve growth and branching during development, implying a similarity between neuronal subtypes in terms of nerve ...
RET-independent signaling by GDNF ligands and GFRα receptors
(Springer, 2020-07)
The discovery in the late 1990s of the partnership between the RET receptor tyrosine kinase and the GFRα family of GPI-anchored co-receptors as mediators of the effects of GDNF family ligands galvanized the field of ...
Intra spinal administration of Netrin-1 promotes locomotor recovery after complete spinal cord transection
(Mary Ann Liebert, 2021-08)
Complete spinal cord lesions interrupt the connection of all axonal projections with their neuronal targets below and above the lesion site. In particular, the interruption of connections with the neurons at lumbar segments ...
Dosage of amyloid precursor protein affects axonal contact guidance in Down syndrome
(Federation of American Societies for Experimental Biology, 2014-01)
Amyloid precursor protein (APP), encoded on Hsa21, functions as a cell adhesion molecule (CAM) in axonal growth cones (GCs) of the developing brain. We show here that axonal GCs of human fetal Down syndrome (DS) neurons ...
Activity-dependent competition regulates motor neuron axon pathfinding via PlexinA3
(National Academy Of Sciences, 2013-01)
The role of electrical activity in axon guidance has been extensively studied in vitro. To better understand its role in the intact nervous system, we imaged intracellular Ca2+ in zebrafish primary motor neurons (PMN) ...
Molecular complexity of visual mapping: A challenge for regenerating therapy
(Shenyang Editorial Dept Neural Regeneration Res, 2019-09)
Investigating the cellular and molecular mechanisms involved in the development of topographically ordered connections in the central nervous system constitutes an important issue in neurobiology because these connections ...
In Situ, Light-Guided Axon Growth on Biomaterials via Photoactivatable Laminin Peptidomimetic IK(HANBP)VAV
(American Chemical Society, 2018-12)
The ability to guide the growth of neurites is relevant for reconstructing neural networks and for nerve tissue regeneration. Here, a biofunctional hydrogel that allows light-based directional control of axon growth in ...
Exposure to enriched environment rescues anxiety-like behavior and miRNA deregulated expression induced by perinatal malnutrition while altering oligodendrocyte morphology
(Pergamon-Elsevier Science Ltd, 2019-06)
Maternal malnutrition is one of the major early-life adversities affecting the development of newborn's brain and is associated with an increased risk to acquire cognitive and emotional deficiencies later in life. Studies ...