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Designing improved active peptides for therapeutic approaches against infectious diseases
(Pergamon-Elsevier Science Ltd, 2018-03)
Infectious diseases are one of the main causes of human morbidity and mortality. In the last few decades, pathogenic microorganisms’ resistance to conventional drugs has been increasing, and it is now pinpointed as a major ...
Synergistic and antibiofilm activity of the antimicrobial peptide P5 against carbapenem-resistant Pseudomonas aeruginosa
(Elsevier Science, 2019-07)
In the search for new antimicrobial molecules, antimicrobial peptides (AMPs) offer a viable alternative to conventional antibiotics, as they physically disrupt the bacterial membranes, leading to membrane disruption and ...
Genetic Analysis of Signal Peptides in Amphibian Antimicrobial Secretions
(Indian Academy of Sciences, 2018-12)
Amphibian secretion is an important source of bioactive molecules that naturally protect the skin against noxious microorganisms. Collectively called antimicrobial peptides (AMPs), these molecules have a wide spectrum of ...
Interactions of “de novo” designed peptides with bacterial membranes: Implications in the antimicrobial activity
(Elsevier Science, 2020-11)
Antimicrobial peptides are small molecules that display antimicrobial activity against a wide range of pathogens. In a previous work, by using model membranes we studied P6, a peptide that shows no antimicrobial activity, ...
A coarse-grained approach to studying the interactions of the antimicrobial peptides aurein 1.2 and maculatin 1.1 with POPG/POPE lipid mixtures
(Springer, 2018-08)
In the present work we investigated the differential interactions of the antimicrobial peptides (AMPs) aurein 1.2 and maculatin 1.1 with a bilayer composed of a mixture of the lipids 1-palmitoyl-2-oleoyl-sn-glycero-3-pho ...
Leptodactylus latrans amphibian skin secretions as a novel source for the isolation of antibacterial peptides
(Molecular Diversity Preservation International, 2018-11)
Amphibians´ skin produces a diverse array of antimicrobial peptides that play a crucial role as the first line of defense against microbial invasion. Despite the immense richness of wild amphibians in Argentina, current ...
Interaction of acylated and substituted antimicrobial peptide analogs with phospholipid-polydiacetylene vesicles. Correlation with their biological properties
(Wiley Blackwell Publishing, Inc, 2011-07)
A series of peptide analogs based on region 6-22 of Plantaricin 149 sequence were synthesized. The interaction between these analogs and phospholipid-polydiacetylene vesicles was investigated to evaluate the ability of the ...
Identification of new ocellatin antimicrobial peptides by cdna precursor cloning in the frame of this family of intriguing peptides
(Multidisciplinary Digital Publishing Institute, 2020-11)
Ocellatins are a family of antimicrobial peptides found exclusively in the Leptodactylus genus. To date, 10 species have been studied and more than 23 peptides described. Here we report the sequences of five new peptides ...
Successful production of the potato antimicrobial peptide Snakin-1 in baculovirus-infected insect cells and development of specific antibodies
(2017)
Background: Snakin-1 (StSN1) is a broad-spectrum antimicrobial cysteine-rich peptide isolated from Solanum tuberosum. Its biotechnological potential has been already recognized since it exhibits in vivo antifungal and ...
Differential interaction of antimicrobial peptides with lipid structures studied by coarse-grained molecular dynamics simulations
(Molecular Diversity Preservation International, 2017-10)
In this work; we investigated the differential interaction of amphiphilic antimicrobial peptides with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) lipid structures by means of extensive molecular dynamics ...