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Articaine interaction with phospholipid bilayers
(Elsevier Science, 2020-12)
Local anesthetics promote analgesia by interacting with excitable membranes. Articaine (ATC) has a unique composition among local anesthetics as it possesses a thiophene instead of the typical phenyl ring. Aiming to ...
Coarse grained simulations of local anesthetics encapsulated into a liposome
(American Chemical Society, 2010-05)
We investigated the encapsulation of prilocaine (PLC), an aminoamide local anesthetic widely used in dentistry, into a small unilamellar liposome. We extended a recently developed coarse grained model to access the problem ...
Molecular dynamics study of uncharged bupivacaine enantiomers in phospholipid bilayers
(John Wiley & Sons Inc., 2012-09)
To investigate the effects of the uncharged bupivacaine (BVC) on the properties of model membranes of 1-palmitoyl- 2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC), we have performed a series of molecular dynamics simulations. ...
Flunitrazepam partitioning into natural membranes increases surface curvature and alters cellular morphology
(Elsevier Ireland, 2000-12-15)
In recent studies, we showed that flunitrazepam (FNTZ) and other benzodiazepines interact with artificial phospholipid membranes locating at the polar head group region, inducing a membrane expansion, reducing the molecular ...
Flunitrazepam–Membrane Binding: A Sensor for Drug-Induced GABAA-R and Membrane Structure Changes
(Elsevier Academic Press Inc., 2016)
Flunitrazepam (FNZ) is a sedative–hypnotic benzodiazepine with important therapeutic usefulness and significant abuse liability. Its capability to induce anterograde amnesia favors FNZ use as a “date-rape drug” administered ...
Effects of gabergic phenols on the dynamic and structure of lipid bilayers: A molecular dynamic simulation approach
(Public Library of Science, 2019-06)
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the vertebrate and invertebrate nervous system. GABAA receptors are activated by GABA and their agonists, and modulated by a wide variety of recognized ...
In vitro alteration on erythrocytes mechanical properties by propofol, remifentanil and vecuronium
(Academic Press Inc Elsevier Science, 2021-05)
Several studies report flow disturbance and microcirculation disorders upon anesthesia treatment. These alterations are often related to blood rheology changes. In this work, it was attempted to make a detailed description ...