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Articaine interaction with phospholipid bilayers
(Elsevier Science, 2020-12)
Local anesthetics promote analgesia by interacting with excitable membranes. Articaine (ATC) has a unique composition among local anesthetics as it possesses a thiophene instead of the typical phenyl ring. Aiming to ...
Coarse grained simulations of local anesthetics encapsulated into a liposome
(American Chemical Society, 2010-05)
We investigated the encapsulation of prilocaine (PLC), an aminoamide local anesthetic widely used in dentistry, into a small unilamellar liposome. We extended a recently developed coarse grained model to access the problem ...
Molecular dynamics study of uncharged bupivacaine enantiomers in phospholipid bilayers
(John Wiley & Sons Inc., 2012-09)
To investigate the effects of the uncharged bupivacaine (BVC) on the properties of model membranes of 1-palmitoyl- 2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC), we have performed a series of molecular dynamics simulations. ...