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Benzocaine-loaded polymeric nanocapsules: Study of the anesthetic activities
(Wiley-Blackwell, 2012-03-01)
This paper describes a comparison of different polymeric nanocapsules (NCs) prepared with the polymers poly(d,l-lactide-co-glycolide), poly(l-lactide) (PLA), and poly(e-caprolactone) and used as carrier systems for the ...
Physicochemical Stability of Poly(lactide-co-glycolide) Nanocapsules Containing the Local Anesthetic Bupivacaine
(Soc Brasileira Quimica, 2010-01-01)
This paper describes the preparation of poly(DL-lactide-co-glicolide) (PLGA) nanocapsules as a drug carrier system for the local anesthetic bupivacaine. The system was characterized and its stability investigated. The ...
Screening of Formulation Variables for the Preparation of Poly(epsilon-caprolactone) Nanocapsules Containing the Local Anesthetic Benzocaine
(Amer Scientific Publishers, 2011-03-01)
In this work we describe the screening of four parameters in the preparation, by nanoprecipitation, of poly(epsilon-caprolactone) nanocapsules, used as a drug carrier system for the local anesthetic, benzocaine. A 2(4-1) ...
Poly(Lactide-co-Glycolide) Nanocapsules Containing Benzocaine: Influence of the Composition of the Oily Nucleus on Physico-Chemical Properties and Anesthetic Activity
(Springer/plenum Publishers, 2011-08-01)
The aim of this work was to investigate the influence of the oily nucleus composition on physico-chemical properties and anesthetic activity of poly (lactide-co-glycolide) nanocapsules with benzocaine.Nanocapsules containing ...
Efeito sinérgico entre a dexmedetomidina e a ropivacaína 0,75% na anestesia peridural
(2008-03-01)
BACKGROUND. This study aimed to evaluate clinical characteristics of epidural anesthesia performed with 0.75% ropivacaine associated with dexmedetomidine. METHODS. Forty patients scheduled for hernia repair or varicose ...
Anestésicos locais: interação com membranas biológicas e com o canal de sódio voltagem-dependente
(Sociedade Brasileira de Química, 2008-01-01)
Many theories about the mechanism of action of local anesthetics (LA) are described in the literature. Two types of theories can be distinguished: those that focus on the direct effects of LA on their target protein in the ...
Comparative analysis of tissue reactions to anesthetic solutions: histological analysis in subcutaneous tissue of rats.
(2003-12-01)
Postanesthetic pain is a relatively common complication after local anesthesia. This complication may be caused by the anesthetic technique or by the anesthetic solution used. Tissue reactions induced by the anesthetic ...
Associacao de opioides lipofilicos a bupivacaina na anestesia peridural. Ha vantagem no aumento da dose do opioide?
(1998-11-30)
Background and Objectives: - The effects of associating lipophilic opioids to local anesthetics in epidural anesthesia are not well defined. There are still questions and controversies about opioid doses to be used and ...
Peridural com ropivacaina a 1%: Experiencia com volume proporcional a estatura
(1998-01-01)
Background and Objectives - Ropivacaine - a local amino amide anesthetic agent - is a plain S enantiomer which makes it a potent and low toxicity drug. The aim of our study was to evaluate 1% ropivacaine for epidural block ...
Preparation and characterization of poly(ε-caprolactone) nanospheres containing the local anesthetic lidocaine
(2013-01-01)
The objective of this work was to develop a modified release system for the local anesthetic lidocaine (LDC), using poly(ε-caprolactone) (PCL) nanospheres (NSs), to improve the pharmacological properties of the drug when ...