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Effects of (−)-6,6′-dinitrohinokinin on adult worms of Schistosoma mansoni: A proteomic analyses
(2016-05-01)
Schistosomiasis, a chronic disease that affects million people worldwide, is caused by trematodeflukes of the genus Schistosoma. The lack of an anti-schistosomiasis vaccine and massive monother-apy with praziquantel ...
In vitro and in vivo anthelmintic activity of (-)-6,6 '-dinitrohinokinin against schistosomula and juvenile and adult worms of Schistosoma mansoni
(Elsevier B.V., 2015-09-01)
The chemotherapy of schistosomiasis relies on the use of praziquantel. However, concerns over drug resistance have encouraged the search for new drug leads. This paper is the first report on the in vitro and in vivo activity ...
In vitro schistosomicidal activity of the lignan ( )-6,60-dinitrohinokinin (dnhk) loaded into poly(lactic-co-glycolic acid) nanoparticles against schistosoma mansoni
(2017-01-01)
Context: ( )-6,60-Dinitrohinokinin (DNHK) display remarkable antiparasitic activity and was, therefore, incorporated into a nanoparticle formulation. Objective: Incorporation of DNHK in poly lactic-co-glycolic acid (PLGA) ...
Evaluation of lignan-loaded poly(ε-caprolactone) nanoparticles: synthesis, characterization, in vivo and in silico schistosomicidal activity
(2021-01-01)
Lignan dinitrohinokinin displays important biological activities, which led to the preparation of its poly-ε-caprolactone nanoparticles. Kinetics analysis revealed initially slow drug release followed by a prolonged, ...
COX Inhibition Profiles and Molecular Docking Studies of the Lignan Hinokinin and Some Synthetic Derivatives
(2018-01-01)
Encouraged by the anti-inflammatory activity of hinokinin in vivo, which is also observed for the analogues dinitrohinokinin and diidrocubebin, herein we used in vitro and in silico methods to assess their selectivity ...
Trypanosoma cruzi: Evaluation of (-)-cubebin derivatives activity in the messenger RNAs processing
(2011-08-01)
No fully effective treatment has been developed since the discovery of Chagas' disease. Since drug-resistant Trypanosoma cruzi strains are occurring and the current therapy is effective in the acute phase but with various ...
Trypanosoma cruzi: Evaluation of (-)-cubebin derivatives activity in the messenger RNAs processing
(2011-08-01)
No fully effective treatment has been developed since the discovery of Chagas' disease. Since drug-resistant Trypanosoma cruzi strains are occurring and the current therapy is effective in the acute phase but with various ...
Síntese e caracterização de nanopartículas poliméricas para veiculação de lignanas bioativas
(Universidade Estadual Paulista (Unesp), 2018-04-20)
Os produtos naturais são uma fonte inesgotável de compostos químicos com as mais variadas propriedades biológicas, entretanto, muitos deles têm baixa biodisponibilidade e/ou são degradados pelas condições fisiológicas, o ...
Trypanosoma cruzi: evaluation of (-)-cubebin derivatives activity in the messenger RNAs processing
(SPRINGER, 2011)
No fully effective treatment has been developed since the discovery of Chagas` disease. Since drug-resistant Trypanosoma cruzi strains are occurring and the current therapy is effective in the acute phase but with various ...