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Systemic and intra-accumbal administration of the 5-ht1b receptor agonist CP94253 modulates oral self-administration of ethanol in ratsLa administración sistémica e intra-accumbens del agonista 5-HT1B CP94253 modula la auto-administración oral de etanol en ratas
(Universidad Nacional de Córdoba, 2022)
Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2A receptor and SIRT1–PGC-1α axis
(National Academy of Sciences, 2019-05)
Mitochondria in neurons, in addition to their primary role in bioenergetics, also contribute to specialized functions, including regulation of synaptic transmission, Ca2+ homeostasis, neuronal excitability, and stress ...
Serotonergic modulation of basolateral amygdala nucleus in the extinction of reward-driven learning: The role of 5-HT bioavailability and 5-HT1A receptor
(Elsevier Science, 2021)
Serotonin (5-HT) neurotransmission has been associated with reward-related behaviour. Moreover, the serotonergic system modulates the basolateral amygdala (BLA), a structure involved in reward encoding, and reward prediction ...
5-HT2A receptor deficiency alters the metabolic and transcriptional, but not the behavioral, consequences of chronic unpredictable stress
(Elsevier Inc, 2017-12)
Chronic stress enhances risk for psychiatric disorders, and in animal models is known to evoke depression-like behavior accompanied by perturbed neurohormonal, metabolic, neuroarchitectural and transcriptional changes. ...
A Novel Mechanism of Modulation of 5-HT3A Receptors by Hydrocortisone
(Cell Press, 2011-01)
Modulation of Cys-loop receptors by steroids is of physiological and therapeutical relevance. Nonetheless, its molecular mechanism has not been elucidated for serotonin (5-HT) type 3 receptors. We deciphered the mechanism ...
Adrenalectomía y receptor 5-HT1A: un análisis microestructural de la conducta alimentaria
(Acta ComportamentaliaActa Comportamentalia: Revista Latina de Análisis del Comportamiento, 2013)
Modulation of gaba release from the thalamic reticular nucleus by cocaine and caffeine: role of serotonin receptors
(Wiley, 2015-10)
Serotonin receptors are targets of drug therapies for a variety of neuropsychiatric and neurodegenerative disorders. Cocaine inhibits the re-uptake of serotonin (5-HT), dopamine, and noradrenaline, whereas caffeine blocks ...
Orthosteric and Allosteric Activation of Human 5-HT3A Receptors
(Cell Press, 2020-10-20)
The serotonin type 3 receptor (5-HT 3) is a ligand-gated ion channel that converts the binding of the neurotransmitter serotonin (5-HT) into a transient cation current that mediates fast excitatory responses in peripheral ...
Tricyclic antidepressants inhibit homomeric Cys-loop receptors by acting at different conformational states
(Elsevier Science, 2008-04)
Tricyclic antidepressants not only inhibit monoamine reuptake but also modulate Cys-loop receptors. However, it is not understood how this modulation is involved in their therapeutic effects. We analyzed the mechanisms of ...
Commentary: Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift
(Frontiers Research Foundation, 2015-08)
A commentary on Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift by Hertz, L., Rothman, D. L., ...