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Localization of TREK-1, a two-pore-domain K+ channel in the peripheral vestibular system of mouse and rat
(2004)
The distribution of two-pore-domain (2P-domain) K+ channels of the TREK subfamily was studied using immunocytochemistry in the peripheral vestibular system of mouse and rat. Using RT-PCR, the mRNA for TREK-1, but not for ...
Calcium-activated potassium channels
(Elsevier Ltd, 1998)
Calcium-activated potassium channels are fundamental regulators of neuronal excitability, participating in interspike interval and spike-frequency adaptation. For large-conductance calcium-activated potassium (BK) channels, ...
Structure-based Discovery of New Two-Pore-Domain Potassium Channels TASK blockers
(2017)
The two-pore domain potassium (K2P) channel TASK-3 is a highly expressed
in hippocampus, cerebellum and cortical areas of the brain. Besides regulating
neurotransmitter functions, TASK-3 has an oncogenic potential and it ...
Rational drug design targeting two-pore domian potassium channels TASK. Theoretical - Experimental approximation
(2014)
TASK-‐3
is
a
two-‐pore
domain
potassium
(K2P)
channel
highly
expressed
in
hippocampus,
cerebellum,
and
cortex.
TASK-‐3
regulates
neurotransmitter
functions
and
has
been
identified
as
an
oncogenic
potassium
channel
and ...
Study and discovery of TASK potassium channels modulators: A theoretical and experimental approach
(2016)
TASK-‐3
is
a
two-‐pore
domain
potassium
(K2P)
channel
highly
expressed
in
hippocampus,
cerebellum,
and
cortex.
TASK-‐3
regulates
neurotransmitter
functions
and
has
been
identified
as
an
oncogenic
potassium
channel
and ...
Role Of The Fenestrations For The Binding Of A1899 To Task-1 Potassium Channel
(2016)
A1899 is a potent and highly selective antagonist of the two-pore domain potassium (K2P) channel TASK-1. It was
previously reported that A1899 acts as an open-channel blocker and binds to residues of the P1, P2 regions, ...
Structure-based Discovery of Potential Two-Pore-Domain Potassium Channel TASK-3 (K2P9.1) modulators
(2017)
TASK-3 is a two-pore domain potassium (K2P) channel highly expressed in
hippocampus, cerebellum, and cortex. TASK-3 regulates neurotransmitter functions and has
been identified as an oncogenic potassium channel and it is ...
Cellular localization of TWIK-1, a two-pore-domain potassium channel in the rodent inner ear
(Elsevier, 2003)
K+ channels in the inner ear regulate the secretion and homeostasis of K+, i.e. the flux of K+ ions required to ensure good mechanosensory transduction. We studied the expression and cellular localization of TWIK-1 and ...