Role Of The Fenestrations For The Binding Of A1899 To Task-1 Potassium Channel

Abstract

A1899 is a potent and highly selective antagonist of the two-pore domain potassium (K2P) channel TASK-1. It was previously reported that A1899 acts as an open-channel blocker and binds to residues of the P1, P2 regions, the M2, M4 segments and the halotha