Structure-based Discovery of Potential Two-Pore-Domain Potassium Channel TASK-3 (K2P9.1) modulators

Abstract

TASK-3 is a two-pore domain potassium (K2P) channel highly expressed in hippocampus, cerebellum, and cortex. TASK-3 regulates neurotransmitter functions and has been identified as an oncogenic potassium channel and it is overexpressed in different cancer