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Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal Blockage
(2015-01-01)
Dendritic cells (DCs), the most important professional antigen-presenting cells (APC), play crucial role in both immunity and tolerance. It is well known that DCs are able to mount immune responses against foreign antigens ...
Enhanced immunization techniques to obtain highly specific monoclonal antibodies
(2018-01-02)
Despite fast advances in genomics and proteomics, monoclonal antibodies (mAbs) are still a valuable tool for areas such as the evolution of basic research in stem cells and cancer, for immunophenotyping cell populations, ...
Vitamin D Deficiency and Rheumatoid Arthritis
(2017-06-01)
Vitamin D (VitD) is a hormone primarily synthesized in human skin under the stimulation of ultraviolet radiation. Beyond its endocrine role in bone metabolism, VitD is endowed with remarkable immunomodulatory properties. ...
Expression of human leucocyte antigen-G primarily targets affected skin of patients with psoriasis
(Wiley-Blackwell, 2010-10-01)
P>BackgroundThe nonclassical human leucocyte antigen (HLA)-G molecule has been well recognized as a tolerogenic molecule and few studies have evaluated the role of the molecule in inflammatory cutaneous autoimmune ...
The role of HLA-G molecule and HLA-G gene polymorphisms in tumors, viral hepatitis, and parasitic diseases
(Frontiers Research Foundation, 2015-02-02)
Considering that the non-classical HLA-G molecule has well-recognized tolerogenic properties, HLA-G expression is expected to be deleterious when present in tumor cells and in cells chronically infected by viruses, whereas ...