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Inteins in pathogenic fungi: a phylogenetic tool and perspectives for therapeutic applications
(Instituto Oswaldo Cruz, Ministério da Saúde, 2009-05-01)
Inteins or internal proteins are coding sequences that are transcribed and translated with flanking sequences (exteins). After translation, the inteins are excised by an autocatalytic process and the host protein assumes ...
MAPK pathways regulation by DUSP1 in the development of osteosarcoma: Potential markers and therapeutic targets
(Wiley, 2017)
Osteosarcoma (OS) is the most frequent primary bone tumor that affect children and adolescents. This tumor is highly aggressive with high risk of metastasis and the implementation of new drugs has not been successful. The ...
MAPK7 Gene Controls Proliferation, Migration and Cell Invasion in Osteosarcoma
(Wiley-Blackwell, 2016)
Osteosarcomas (OS) are the most common malignant bone tumors, and the identification of useful tumor biomarkers and target proteins is required to predict the clinical outcome of patients and therapeutic response as well ...
ERBB2 gene as a potential therapeutic target in small bowel adenocarcinoma
(Elsevier, 2014-07)
Toxoplasmose: perspectivas no estudo de novos alvos terapêuticos
(Sociedade Brasileira de Química, 2018)
Targeting the Inflammatory Pathway as a Therapeutic Tool for Major Depression
(Karger, 2014-01-01)
In the last decades convergent findings from several lines of evidence has revealed a robust association between major depressive disorder (MDD) and inflammatory pathways. Despite this, the translation of these findings ...
Toxicity of the therapeutic potassium permanganate to tilapia Oreochromis niloticus and to non-target organisms Ceriodaphnia dubia (microcrustacean cladocera) and Pseudokirchneriella subcapitata (green microalgae)
(Elsevier B.V., 2011-12-21)
Potassium permanganate is a chemical compound widely used in aquaculture for the control and removal of parasites, and in the prevention of diseases caused by bacteria and fungi. However, this compound can be toxic to fish, ...
Cytostatic in vitro Effects of DTCM-Glutarimide on Bladder Carcinoma Cells
(Asian Pacific Organization Cancer Prevention, 2012-01-01)
Bladder cancer is a common malignancy worldwide. Despite the increased use of cisplatin-based combination therapy, the outcomes for patients with advanced disease remain poor. Recently, altered activation of the PI3K/Akt/mTOR ...
Vancomycin Therapeutic Targets and Nephrotoxicity in Critically Ill Children With Cancer
(Lippincott Williams & Wilkins, 2016)
To obtain pharmacokinetic and pharmacodynamic data for vancomycin in a cohort of critically ill pediatric oncology patients, we analyzed 256 measurements of vancomycin concentrations in 94 patients. Variables were tested ...
Immunohistochemical analysis of pdgfr-alpha, pdgfr-beta and c-abl in retinoblastoma: potential therapeutic targets
(Karger, 2016)
Background: Our laboratory previously reported that imatinib mesylate (IM) has an inhibitory effect on two retinoblastoma (Rb) cell lines in vitro. Aims: The purpose of this project was to determine the immunoexpression ...