Buscar
Mostrando ítems 1-10 de 218
Therapeutic targeting of autophagy in myocardial infarction and heart failure
(Taylor & Francis, 2016)
Introduction: Myocardial infarction (MI) is the leading cause of death. When MI is not lethal, heart failure (HF) is a major consequence with high prevalence and poor prognosis. The targeting of autophagy represents a ...
Estimation of the Probability to Target Attainment to the Pharmacokinetic/ Pharmacodynamic Index of Ertapenem in Elderly Inpatients
(Association of Pharmaceutical Teachers of India (APTI), 2020)
Background: Infectious diseases are one of the most causes of hospitalization and
death in adults in the elderly and this population is prone to develop complications
and pharmacokinetic/pharmacodynamic changes. Objectives: ...
From ligand design to therapeutic efficacy: the challenge for nicotinic receptor research
(ELSEVIER SCI LTD, 2005-12)
S-Nicotine, the principal psychoactive constituent of Nicotiana tabacum, underpins addiction to tobacco smoking. Although tobacco consumption is a leading cause of death worldwide, nicotine itself is also proposed to have ...
Exploiting the natural properties of extracellular vesicles in targeted delivery towards specific cells and tissues
(MDPI, 2020)
Extracellular vesicles (EVs) are important mediators of intercellular communication that participate in many physiological/pathological processes. As such, EVs have unique properties related to their origin, which can be ...
Targeting the unfolded protein response for disease intervention
(Taylor & Francis, 2015)
Introduction: The accumulation of misfolded proteins in the endoplasmic reticulum (ER)
generates a stress condition that engages the unfolded protein response (UPR). The UPR is an
adaptive reaction that aims to reestablish ...
Inflammation: A major target for compounds to control Alzheimer's Disease
(IOS Press, 2020)
Several hypotheses have been postulated to explain how Alzheimer's disease is triggered, but none of them provide a unified view of its pathogenesis. The dominant hypothesis based on build-ups of the amyloid-beta peptide ...
Botulinum neurotoxin: Evolution from poison, to research tool - Onto medicinal therapeutic and future pharmaceutical panacea
(2007)
Botulinum neurotoxin (BoNT), for more than a hundred years, has been a recognized poisonous principle in spoiled food. As its chemical structure became unraveled, and as more knowledge was gained over its mechanism of ...
(off) Targeting UPR signaling: the race toward intervening ER proteostasis
(Taylor & Francis, 2018)
(off)Targeting UPR signaling: the race toward intervening ER proteostasis
(Taylor and Francis Ltd, 2018)
Mitochondrial dynamics: A potential new therapeutic target for heart failure Dinámica mitocondrial: un potencial nuevo blanco terapéutico para la insuficiencia cardiaca
(2011)
Mitochondria are dynamic organelles able to vary their morphology between elongated interconnected mitochondrial networks and fragmented disconnected arrays, through events of mitochondrial fusion and fission, respectively. ...