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Insight into nanoparticle cellular uptake and intracellular targeting
(2014)
Collaborative efforts from the fields of biology, materials science, and engineering are leading to exciting progress in the development of nanomedicines. Since the targets of many therapeutic agents are localized in ...
Intracellular signaling pathways involved in childhood acute lymphoblastic leukemia; molecular targets
(Indian Journal of Hematology and Blood Transfusion, 2020)
Neuroinflammation : A therapeutic target of cotinine for the treatment of psychiatric disorders?
(2016-03-01)
Neuroinflammation is a common characteristic of several mental health conditions such as major depression, bipolar disorder, post-traumatic stress disorder (PTSD) and schizophrenia (SCHZ). Inflammatory processes trigger ...
Neuroprotective effects of the catalytic subunit of telomerase : A potential therapeutic target in the central nervous system
(2016-07-01)
Senescence plays an important role in neurodegenerative diseases and involves key molecular changes induced by several mechanisms such as oxidative stress, telomere shortening and DNA damage. Potential therapeutic strategies ...
Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer
(2015)
Abstract
Background
Poor prognosis in gallbladder cancer is due to late presentation of the disease, lack of reliable biomarkers for early diagnosis and limited targeted ...
Therapeutic hypothermia for acute brain injuries
(2015)
Abstract
Therapeutic hypothermia, recently termed target temperature management (TTM), is the cornerstone of neuroprotective strategy. Dating to the pioneer works of Fay, nearly 75 years of basic and clinical ...
Therapeutic strategies based on polymeric microparticles
(Hindawi Limited, 2012)
The development of the field of materials science, the ability to perform multidisciplinary scientific work, and the need for novel administration technologies that maximize therapeutic effects and minimize adverse reactions ...
Is VEGF a key target of cotinine and other potential therapies against Alzheimer disease?
(2017)
Background: The vascular endothelial growth factor (VEGF) is a neuroprotective cytokine that promotes neurogenesis and angiogenesis in the brain. In animal models, it has been shown that environmental enrichment and exercise, ...
Specialized Proresolving Lipid Mediators : A Potential Therapeutic Target for Atherosclerosis
(2022-03-01)
Cardiovascular disease (CVD) is a global public health issue due to its high morbidity, mortality, and economic impact. The implementation of innovative therapeutic alternatives for CVD is urgently required. Specialized ...