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Challenging identification of polymorphic mixture: Polymorphs I, II and III in olanzapine raw materials
(Elsevier Science, 2019-02-10)
Olanzapine (OLZ), a drug for the treatment of schizophrenia, presents in more than 60 crystal forms. Polymorphs I, II and III were reported, however, the preparation conditions for pure II and III have not been reported. ...
A comprehensive approach toward concomitant triclabendazole polymorphism in pharmaceutical products
(Elsevier, 2021-04)
Triclabendazole (TCB) is a highly effective and low-cost anti-parasitic active pharmaceutical ingredient (API) used in the treatment of fascioliasis, a neglected tropical disease caused by Fasciola hepatica. It belongs to ...
Impact of A118G polymorphism on the Mu opioid receptor function in pain
(OMICS Publishing Group, 2013-07-07)
Mu Opioid Receptor (MOR) activation by exogenous or endogenous agonists causes reduction of pain threshold after a noxious stimulus, relieving pain sensation.MOR is encoded by OPRM1 gene and its messenger RNA ...
Dissolution properties, solid-state transformation and polymorphic crystallization: Progesterone case study
(Taylor & Francis, 2014-11)
Progesterone is a natural steroid hormone and a poor soluble drug which presents two polymorphs (forms 1 and 2). Different methods to obtain form 2 were tested and a complete solid-state characterization of both polymorphs ...
A monoclinic form of dendocarbin A: A borderline case of one-dimensional isostructural polymorphism
(International Union of Crystallography, 2015-04)
The title compound, dendocarbin A [systematic name: (1R,5aS,9aS,9bR)-1-hydroxy-6,6,9a-trimethyldodecahydronaphtho[1,2-c]furan-3-one], C15H22O3, is a sesquiterpene lactone isolated from Drimys winteri var chilensis. The ...
Chemometric study of the excipients’ influence on polymorphic-behavior: Mefenamic acid as case of study
(Elsevier Science, 2019-06)
The assessment of polymorphism is a problematical issue for regulatory agencies, because variations among crystalline forms of active pharmaceutical ingredient (API) can lead to changes in the efficacy and safety of ...
TYR Gene in Llamas: Polymorphisms and Expression Study in Different Color Phenotypes
(Frontiers, 2019-06)
Tyrosinase, encoded by TYR gene, is an enzyme that plays a major role in mammalian pigmentation. It catalyzes the oxidation of L-dihydroxy-phenylalanine (DOPA) to DOPA quinone, a precursor of both types of melanin: eumelanin ...
Against the central-marginal model: Three cases in chromosomally polymorphic grasshoppers (Orthoptera: Acrididae)
(Czech Academy of Sciences, 2012-07)
The central-marginal model is widely accepted in chromosomally polymorphic species of Drosophila. In fact, geographically and ecologically central populations of Drosophila show higher levels of polymorphism for paracentric ...
Polymorphism of a widely used building block for halogen-bonded assemblies: 1,3,5-Trifluoro-2,4,6-Triiodobenzene
(International Union of Crystallography, 2017-09)
After reporting the structure of a new polymorph of 1,3,5-Trifluoro-2,4,6-Triiodobenzene (denoted BzF3I3), C6F3I3, (I), which crystallized in the space group P21/c, we perform a comparative analysis with the already reported ...
Growth hormone receptor gene polymorphism. Spontaneous catch up growth in small for gestational age patientsPolimorfismo del gen del receptor de la hormona de crecimiento. Crecimiento postnatal espontáneo en niños pequeños para la edad gestacional
(Medicina (Buenos Aires), 2021-10)
The growth hormone receptor (GHR) mediates the effect of growth hormone (GH) on linear growth and metabolism. In humans, it exists as two isoforms differing by the retention or exclusion of exon 3; a full-length GHR isoform ...