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Central leptin replacement enhances chemorespiratory responses in leptin-deficient mice independent of changes in body weight
(Springer, 2012-08-01)
Previous studies showed that leptin-deficient (ob/ob) mice develop obesity and impaired ventilatory responses to CO2 . In this study, we examined if leptin replacement improves chemorespiratory responses to hypercapnia (7 ...
Effects of a single nucleotide polymorphism in the leptin gene on the productive traits of dairy buffaloes (Bubalus bubalis)
(2013-08-01)
The gene responsible for coding the leptin hormone has been associated with productive and reproductive traits in cattle. In dairy cattle, different polymorphisms found in the leptin gene have been associated with several ...
Validação de radioimunoensaio para quantificação de leptina plasmática bovina
(2010-12-01)
Due necessity of better understanding leptin and reproduction relations, a specific radioimmunoassay (RIA) to bovine leptin was avalidated. First, an antibody production protocol was developed using recombinant equine ...
Leptin promoter gene polymorphism on -2549 position decreases plasma leptin and increases appetite in normal weight volunteers
(Revista Española de Nutrición Humana y Dietética, 2018)
Serum leptin level in hypertensive middle-aged obese women
(Lippincott Williams & Wilkins, 2005-07-01)
The mechanism by which adiposity can raise blood pressure is not fully understood. Leptin has been suggested as a possible cause of the arterial hypertension in obese subjects because leptin induces an increase in sympathetic ...
In vitro evaluation of leptin fragments activity on the ob receptor
(Wiley-Blackwell, 2008-05-01)
In an attempt to identify regions in the leptin molecule responsible for its bioactivity, we tested six related-leptin peptide fragments denoted: Ae-hLEP(23-47)-NH(2) (I), Ac-hLEP(48-71)-NH(2) (II), Ac-hLEP(72-88)-NH(2) ...
Administration of physiologic levels of triiodothyronine increases leptin expression in calorie-restricted obese rats, but does not influence weight loss
(W B Saunders Co-elsevier Inc, 2010-01-01)
Obesity has become a major public health problem, most commonly treated via dietary restriction to promote weight loss. Although leptin and thyroid hormones are involved in the regulation of energy balance, the role of ...
TNF-alpha acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient - Effects on leptin and insulin signaling pathways
(Elsevier B.V., 2007-05-01)
Acting in the hypothalamus, tumor necrosis factor-alpha (TNF-alpha) produces a potent anorexigenic effect. However, the molecular mechanisms involved in this phenomenon are poorly characterized. In this study, we investigate ...
Decrease in circulating glucose, insulin and leptin levels and improvement in insulin resistance at 1 and 3 months after gastric bypass
(F D-communications Inc, 2006-10-01)
Background: Hyperglycemia, insulin resistance and hyperleptinemia are some of the consequences of obesity. Gastric bypass for morbid obesity provides gastric restriction with decreased energy absorption. To confirm and ...
Serum leptin concentration during puberty in healthy nonobese adolescents
(Associação Brasileira de Divulgação Científica, 2003-10-01)
Data obtained during the past five years have indicated that there are important age- and gender-based differences in the regulation and action of leptin in humans. To study the physiological changes of leptin during puberty ...