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Novel Il33 gene polymorphisms associated with asthma are associated with resistance to schistosoma mansoni
(Journal of Allergy and Clinical Immunology, 2013)
Rationale
IL33 is one of the most consistently associated candidate genes for asthma identified by GWAS in diverse ethnic groups. We previously demonstrated GWAS SNPs associated with asthma were also associated with asthma ...
Between the cross and the sword: the crisis of the gene concept
(2007-03)
Challenges to the gene concept have shown the difficulty of preserving the classical molecular concept, according to which a gene is a stretch of DNA encoding a functional product (polypeptide or RNA). The main difficulties ...
Identification and characterization of a class III chitin synthase gene of Moniliophthora perniciosa, the fungus that causes witches’ broom disease of cacao
(2009)
Chitin synthase (CHS) is a glucosyltransferase that converts UDP-N-acetylglucosamine into chitin, one of the main components of fungal cell wall. Class III chitin synthases act directly in the formation of the cell wall. ...
Familial Pseudo-Wolff-Parkinson-White Syndrome
(2006)
Introduction: PRKAG2 plays a role in regulating metabolic pathways, and mutations in this gene are associated with familial ventricular preexcitation, hypertrophic cardiomyopathy, and atrioventricular conduction disturbances. ...
Sequencing of the ST2 Gene Reveals a Haplotype That Determines Serum Total ST2 Levels in Individuals of African Ancestry
(Journal of Allergy and Clinical Immunology, 2013)
Rationale
ST2 (IL1RL1), is an IL1 family receptor that mediates important effectors of Th2 functions. Its soluble form (sST2) neutralizes its ligand, IL-33, by acting as a decoy receptor. Serum sST2 has been used as a ...