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Microtubule-associated protein 1B interaction with tubulin tyrosine ligase contributes to the control of microtubule tyrosination
(2007)
Microtubule-associated protein 1B (MAP1B) is the first microtubule- associated protein to be expressed during nervous system development. MAP1B belongs to a large family of proteins that contribute to the stabilization ...
Case report: Maternal tyrosinemia type 1a under NTBC treatment with tyrosine- and phenylalanine restricted diet in Chile
(Wiley, 2020)
We report the case of a 17-year-old girl with Tyrosinemia type 1a who carried a planned pregnancy to
term while being under 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC, nitisinone)
treatment and a ...
A Tyrosine-Dependent Riboswitch Controls the Expression of a Tyrosyl-tRNA Synthetase from Acidithiobacillus ferrooxidans
(Croatian Chemical Soc, 2016)
Expression of aminoacyl-tRNA synthetases is regulated by a variety of mechanisms at the level of transcription or translation. A T-box dependent transcription termination/antitermination riboswitch system that responds to ...
Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells
(Elsevier, 2015)
A considerable body of evidence exists implicating high levels of free saturated fatty acids in beta pancreatic cell
death, although the molecular mechanisms and the signaling pathways involved have not been clearly ...
The peroxyl radical-induced oxidation of Escherichia coli FtsZ and its single tryptophan mutant (Y222W) modifies specific side-chains, generates protein cross-links and affects biological function
(Elsevier Inc., 2017)
© 2017 Elsevier Inc. FtsZ (filamenting temperature-sensitive mutant Z) is a key protein in bacteria cell division. The wild-type Escherichia coli FtsZ sequence (FtsZwt) contains three tyrosine (Tyr, Y) and sixteen methionine ...
Interim Analysis from the OPTIC Trial - A Dose-Ranging Study of 3 Starting Doses of Ponatinib
(CIG Media Group, 2020)
Free radicals derived from γ-radiolysis of water and AAPH thermolysis mediate oxidative crosslinking of eGFP involving Tyr-Tyr and Tyr-Cys bonds: the fluorescence of the protein is conserved only towards peroxyl radicals
(Elsevier, 2020)
The enhanced green fluorescent protein (eGFP) is one of the most employed variants of fluorescent proteins.
Nonetheless little is known about the oxidative modifications that this protein can undergo in the cellular ...
Unraveling the role of the tyrosine tetrad from the binding site of the epigenetic writer MLL3 in the catalytic mechanism and methylation multiplicity
(MDPI, 2022)
MLL3, also known as KMT2C, is a lysine mono-methyltransferase in charge of the writing of an epigenetic mark on lysine 4 from histone 3. The catalytic site of MLL3 is composed of four tyrosines, namely, Y44, Y69, Y128, and ...
The effects of alpha-methyl-p-tyrosine pretreatment on ethanol-induced narcosis and hypothermia, as well as in the development of tolerance to these effects in UChA and UChB rats
(1990)
We have previously reported that UChA rats (genetically low ethanol consumer) develop tolerance to narcosis time easier than UChB rats (genetically high ethanol consumer). We also have reported that UChA rats develop ...
Effects of kinesin-5 inhibition on dendritic architecture and microtubule organization
(Amer Soc Cell
Biology, 2015)
ABSTRACT Kinesin-5 is a slow homotetrameric motor protein best known for its essential role in the mitotic spindle, where it limits the rate at which faster motors can move microtubules. In neurons, experimental suppression ...